Detailed information of TA system TA202820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4185539..4186055
• Replicon: chromosome
• Accession: NZ_CP075106
• Organism: Salmonella enterica strain CFSAN064276

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5U7R3Q6
• Locus tag: CBI76_RS20295
• Protein ID: WP_023243277.1
• Coordinates: 4185539..4185823 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: CBI76_RS20300
• Protein ID: WP_000212724.1
• Coordinates: 4185813..4186055 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI76_RS20280 (4180655)	4180655..4182307	+	1653	WP_023243275.1	alpha,alpha-phosphotrehalase	-
CBI76_RS20285 (4182716)	4182716..4184854	+	2139	WP_000187821.1	anaerobic ribonucleoside-triphosphate reductase	-
CBI76_RS20290 (4185071)	4185071..4185535	+	465	WP_023243276.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CBI76_RS20295 (4185539)	4185539..4185823	-	285	WP_023243277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CBI76_RS20300 (4185813)	4185813..4186055	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CBI76_RS20305 (4186133)	4186133..4188046	-	1914	WP_001212131.1	BglG family transcription antiterminator	-
CBI76_RS20310 (4188063)	4188063..4188803	-	741	WP_023243278.1	KDGP aldolase family protein	-
CBI76_RS20315 (4188800)	4188800..4189918	-	1119	WP_023243279.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
CBI76_RS20320 (4189902)	4189902..4191035	-	1134	WP_023243280.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10801.62 Da
• Isoelectric Point: 9.6730

>T202820 WP_023243277.1 NZ_CP075106:c4185823-4185539 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T202820 NZ_CP099705:206967-207452 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT202820 WP_000212724.1 NZ_CP075106:c4186055-4185813 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT202820 NZ_CP099705:206692-206979 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: A0A5U7R3Q6

Antitoxin

• AlphaFold DB: A0A5H5JRI5