Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4098796..4099372 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag CBI76_RS19885 Protein ID WP_001131963.1
Coordinates 4099085..4099372 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag CBI76_RS19880 Protein ID WP_000063143.1
Coordinates 4098796..4099098 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS19865 (4095306) 4095306..4097456 + 2151 WP_023244016.1 pyruvate/proton symporter BtsT -
CBI76_RS19870 (4097551) 4097551..4097754 + 204 WP_000460616.1 YbdD/YjiX family protein -
CBI76_RS19875 (4097765) 4097765..4098721 + 957 WP_000612222.1 GTPase -
CBI76_RS19880 (4098796) 4098796..4099098 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
CBI76_RS19885 (4099085) 4099085..4099372 - 288 WP_001131963.1 BrnT family toxin Toxin
CBI76_RS19890 (4099641) 4099641..4100555 - 915 WP_023244015.1 restriction endonuclease -
CBI76_RS19895 (4100753) 4100753..4104262 + 3510 WP_023244014.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T202819 WP_001131963.1 NZ_CP075106:c4099372-4099085 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T202819 NZ_CP099648:73162-73452 [Paraburkholderia fungorum]
GTGAGGCTTGAATGGTCCGCTTTCGCAATAGAGGATCGCGACGCGATTTTTGACTACATCGAAGAAGACCGCCCGCGTGC
TGCTGTGGTCGTGGACGATCGGATCCGGACGCAGGTCAGGCAACTGCTTCAGTTTCCTGAGACTGGCCGTCCAGGCCGCA
TCGAGGGCACCCGCGAACTGGTCATCAGCCGAACACCGTATATCGCGGCCTACCGCATCACGGGCGACACCGTGCGCATC
CTGCGCGTGTTGCACGGCGCGCAGCTATGGCCCGATGAAATATTGGATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT202819 WP_000063143.1 NZ_CP075106:c4099098-4098796 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT202819 NZ_CP099648:72857-73165 [Paraburkholderia fungorum]
ATGGCTGCTAGTGCATTGGTGCAAACGCGCATCGACCCCGTGCTGAAAGAGCGCGCGGCCGCGGTGCTCGACAACATGGG
ACTGACCGTCTCGGACGCCGTCCGTATCCTGCTGACGCGCGTTGCCAACGAGGGTGCGTTGCCGTTCGCCTTTGCGACCG
ACCCGGCCGTACATGACGCCTGGTTTCGCGCGAAGGTGCAGGAAGCATTGGACGATCCGCGCCCCGCTACCCCGGACGAT
GACGTTGAGGCCCATTTCGCCAGGCGCCGCGCCGCGGCCCTTCGCAAAGCCGGCGAAGGTGACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References