Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3496508..3497128 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CBI76_RS17115 Protein ID WP_001280991.1
Coordinates 3496910..3497128 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CBI76_RS17110 Protein ID WP_000344807.1
Coordinates 3496508..3496882 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS17100 (3491647) 3491647..3492840 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CBI76_RS17105 (3492863) 3492863..3496012 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
CBI76_RS17110 (3496508) 3496508..3496882 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CBI76_RS17115 (3496910) 3496910..3497128 + 219 WP_001280991.1 HHA domain-containing protein Toxin
CBI76_RS17120 (3497307) 3497307..3497858 + 552 WP_023243161.1 maltose O-acetyltransferase -
CBI76_RS17125 (3497974) 3497974..3498444 + 471 WP_000136183.1 YlaC family protein -
CBI76_RS17130 (3498500) 3498500..3498640 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CBI76_RS17135 (3498646) 3498646..3498906 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CBI76_RS17140 (3499131) 3499131..3500681 + 1551 WP_023243162.1 EAL domain-containing protein -
CBI76_RS17150 (3500912) 3500912..3501301 + 390 WP_000961285.1 MGMT family protein -
CBI76_RS17155 (3501334) 3501334..3501903 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202815 WP_001280991.1 NZ_CP075106:3496910-3497128 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202815 NZ_CP099647:c2304183-2303881 [Paraburkholderia fungorum]
ATGAAGGCGTTTGTTCTCTCGCCGGCAGCCGAACGCGACCTTGATGATATCTGGGATTACACGGTCACCCGATGGGGAGA
AGTGCAGGCTGAGCGTTACATCCTGAGCATCGAAAGTACCATTGCGGGTCTAGCCGACGGCACCCAGCCAAGTCTGTCCG
CCGCAGACGTGCGGGACGGGTACAGGAAGGCGCTGACTGGAATGCATGTCGTGTTCTTCAGGGAATCGGAAGCGTTGATC
GACGTCATCCGCATCCTGCATCAACAGATGGATATCCCCCGTAGGCTCGGCGACGACAACTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202815 WP_000344807.1 NZ_CP075106:3496508-3496882 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202815 NZ_CP099647:c2304422-2304180 [Paraburkholderia fungorum]
ATGAGCAAAAGCACATCGTTCACGCTCGGTGAGCATTTTTCGGAATTCGTCGATGACCGCGTGCGCAGCGGTCGTTACAG
CACAGCCAGCGACGTGGTCCGCGCCGGCTTGCGCCTGCTCGAGACTGAGGAGGCAAGACTGGAGGCCCTGCGAAGCGCGT
TGATCGAAGGCGAGCAGTCCGGACCGTCGCGCCCGTTTGATTTTCGCAAGTACGTCGCGGGTAAGCGGAACAGGGCCGCA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References