202814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2429995..2430517 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name stbE Uniprot ID A0A5U0LRG3
Locus tag CBI76_RS11805 Protein ID WP_023243932.1
Coordinates 2430233..2430517 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag CBI76_RS11800 Protein ID WP_000885424.1
Coordinates 2429995..2430243 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS11760 (2425455) 2425455..2425637 + 183 WP_001335098.1 hypothetical protein -
CBI76_RS11765 (2425726) 2425726..2426148 + 423 WP_052907448.1 hypothetical protein -
CBI76_RS11770 (2426298) 2426298..2426582 + 285 WP_052907449.1 hypothetical protein -
CBI76_RS11775 (2426584) 2426584..2427372 + 789 WP_052907450.1 hypothetical protein -
CBI76_RS11780 (2427595) 2427595..2428191 + 597 Protein_2313 helix-turn-helix domain-containing protein -
CBI76_RS11785 (2428247) 2428247..2429155 - 909 WP_077909464.1 hypothetical protein -
CBI76_RS11790 (2429306) 2429306..2429638 - 333 WP_023244369.1 DUF1493 family protein -
CBI76_RS11795 (2429628) 2429628..2429843 - 216 WP_000206207.1 hypothetical protein -
CBI76_RS11800 (2429995) 2429995..2430243 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CBI76_RS11805 (2430233) 2430233..2430517 + 285 WP_023243932.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CBI76_RS11810 (2430688) 2430688..2431073 + 386 Protein_2319 RidA family protein -
CBI76_RS11815 (2431125) 2431125..2432204 - 1080 WP_023244370.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
CBI76_RS11820 (2432397) 2432397..2432885 - 489 WP_023243930.1 MarR family winged helix-turn-helix transcriptional regulator -
CBI76_RS11825 (2432930) 2432930..2434438 + 1509 WP_023243929.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11057.82 Da        Isoelectric Point: 10.6500

>T202814 WP_023243932.1 NZ_CP075106:2430233-2430517 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAIYKVTRHRS

Download         Length: 285 bp

>T202814 NZ_CP099645:c2272187-2271891 [Paraburkholderia fungorum]
TTGGAAAAAAGTACGCCTCATTGCAAGCTGGCCGAGGTTCAAAGCTTGGCGCGTGCGGGGAACATCAGAATCACGAAATC
GGCCGTGATTGGAGCCGCGGCACTTGGCCTCGGACCCGCGGCAATCATCGAGACATTGCTGTCGCTCGAGCGCGGGAATT
TTCGAAAAAGCATGACCACGTACGCGGACCATCGGGTCTGGCAGGACGTCTACTGTGCCGTCACGGAAGCAGGCATGGTC
TATTTGAAATTGACGGTGATCGACGACGTTCTTGTCGTGTCATTCAAGGAGTGGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT202814 WP_000885424.1 NZ_CP075106:2429995-2430243 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT202814 NZ_CP099645:c2271888-2271487 [Paraburkholderia fungorum]
ATGAAATGCCCGAACTGCGGCGCGGCCGAACTGGTGCGCGATACGCGCAATATGCGCTATGTCTACAAGGGCGAGACGGC
TGTATTCGAAGCCGTCACGGGTGACTATTGTCCGGCGTGTGACGAGGCGGTGCTCGACATCGACGAAGCCACACGCACCG
GGCAAATGATGCTGGCTTTCAACAAAGAGGTGAATGCCTCGCAAGTGGATCCTGCCTTCATTGCCGCTGTGCGCAAGAAG
CTCGATCTGGACCAGCGCGAGGCAGCGGAGATTTTCGGCGGGGGGGTGAACGCCTTTTCGCGCTACGAAAATGGCAAGAC
CCGGCCGCCGCTCGCTCTGATCAAACTGTTGAAAGTGCTGGACCGGCATCCGGAGCTGCTGGAAGAAGTCAGGGCGAGTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0LRG3

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References