Detailed information of TA system TA020281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1603449..1604035
• Replicon: chromosome
• Accession: NC_002488
• Organism: Xylella fastidiosa 9a5c

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: XF_RS13305
• Protein ID: WP_080507210.1
• Coordinates: 1603449..1603703 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2I6C9
• Locus tag: XF_RS07110
• Protein ID: WP_004085025.1
• Coordinates: 1603700..1604035 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XF_RS07075 (XF1662)	1598509..1598892	+	384	WP_042463212.1	hypothetical protein	-
XF_RS07080 (XF1663)	1599096..1600208	+	1113	WP_042463693.1	Bro-N domain-containing protein	-
XF_RS07085 (XF1664)	1600205..1600513	+	309	WP_023906549.1	DUF1376 domain-containing protein	-
XF_RS07090 (XF1665)	1600510..1601598	+	1089	WP_010894160.1	YdaU family protein	-
XF_RS07095	1601504..1602268	+	765	WP_195780003.1	hypothetical protein	-
XF_RS07100 (XF1666)	1602265..1602678	+	414	WP_010894161.1	hypothetical protein	-
XF_RS07105	1602698..1603396	+	699	WP_042463215.1	hypothetical protein	-
XF_RS13305	1603449..1603703	+	255	WP_080507210.1	type II toxin-antitoxin system HicA family toxin	Toxin
XF_RS07110 (XF1668)	1603700..1604035	+	336	WP_004085025.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
XF_RS07115 (XF1669)	1604297..1604794	+	498	WP_042463169.1	lysozyme	-
XF_RS07120 (XF1670)	1604787..1605116	+	330	WP_010894063.1	phage holin family protein	-
XF_RS07125 (XF1671)	1605106..1605567	+	462	WP_010894064.1	hypothetical protein	-
XF_RS07130 (XF1672)	1605569..1605781	+	213	WP_042463172.1	hypothetical protein	-
XF_RS07135 (XF1673)	1605872..1606270	+	399	WP_010894066.1	hypothetical protein	-
XF_RS13310	1606221..1607771	+	1551	Protein_1393	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9621.10 Da
• Isoelectric Point: 11.2766

>T20281 WP_080507210.1 NC_002488:1603449-1603703 [Xylella fastidiosa 9a5c]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRILVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T20281 NC_002488:1603449-1603703 [Xylella fastidiosa 9a5c]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATATTGGTGAGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12324.07 Da
• Isoelectric Point: 5.6556

>AT20281 WP_004085025.1 NC_002488:1603700-1604035 [Xylella fastidiosa 9a5c]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Nucleotide

• Length: 336 bp

>AT20281 NC_002488:1603700-1604035 [Xylella fastidiosa 9a5c]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAAATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Structures

Antitoxin

• AlphaFold DB: A0A060HAK5