Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1947224..1947814 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name pemK Uniprot ID A0A5Z3IR43
Locus tag CBI76_RS09290 Protein ID WP_023243734.1
Coordinates 1947482..1947814 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A618JW87
Locus tag CBI76_RS09285 Protein ID WP_023243733.1
Coordinates 1947224..1947481 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS09270 (1943886) 1943886..1945841 - 1956 WP_024149369.1 hypothetical protein -
CBI76_RS09275 (1946200) 1946200..1946673 + 474 WP_023244266.1 hypothetical protein -
CBI76_RS09280 (1946670) 1946670..1946876 + 207 WP_023243732.1 helix-turn-helix transcriptional regulator -
CBI76_RS09285 (1947224) 1947224..1947481 + 258 WP_023243733.1 MazE family transcriptional regulator Antitoxin
CBI76_RS09290 (1947482) 1947482..1947814 + 333 WP_023243734.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CBI76_RS09295 (1948649) 1948649..1949533 + 885 WP_031609821.1 integrase domain-containing protein -
CBI76_RS09305 (1950478) 1950478..1951740 - 1263 WP_023244267.1 integrase arm-type DNA-binding domain-containing protein -
CBI76_RS09315 (1952399) 1952399..1952704 - 306 Protein_1828 Arm DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.65 Da        Isoelectric Point: 10.5834

>T202805 WP_023243734.1 NZ_CP075106:1947482-1947814 [Salmonella enterica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVIPVTSGGNFARAAGFTVSLEGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T202805 NZ_CP099627:3941306-3941587 [Paraburkholderia fungorum]
ATGATCACGACATTCGGCGACAAGGCTACGGCAGCAATCTTCCACGGCAAGTTCGTGCATTCACTGCCGCTCTACATGCA
GGCGCTCGCACGCCGCAAGCTGCTGATGATCGATGCCGCGGAGTCCATCCGCAGCCTGCATGCGCCGCCGGGCAACCGGC
TCGAAGCCTTGCAAGGCCAGCGCAGCGGGCAGTGGAGCATTCGCATCAACGCGCAGTGGCGCATCTGTTTTCATTTTGTC
GACGGGGAGGCGCTGAATGTCGAAATTGTCGACTATCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9512.02 Da        Isoelectric Point: 4.4929

>AT202805 WP_023243733.1 NZ_CP075106:1947224-1947481 [Salmonella enterica]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMREEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT202805 NZ_CP099627:3941604-3942059 [Paraburkholderia fungorum]
ATGGTCATCAAACGCTCCGAACTGGGCAGTATCGACTTCTCCGACATCGGCACGGGAGAAAGCATCCCGGAGACTCACCC
GGGGGAGATTCTGCGCAGCGAGTTCCTCGAGCCGCTCGGCATGTCCGTCAATGCGCTCGCACTTGCGCTGCGAGTACCGG
CGCCGCGCATCAACGACATCGTGCGCGGCAAACGCGCCATCTCGGCTGACACCGCACTGCGGCTCGAACGCTACTTTGGC
GCGAGTGCGCAGTTCTGGCTAAATCTGCAGATCGCGTACGACCTGCGCGTCGCCACCGCCGCGGCCGGCGAGCAGATCGA
ACGCGAGATCGAGCCGATGCCCAGGGCGAACCGGCCGAAACTGCCGAAAGTCTCGGCCGAACACGCCCGGGCGGCGGCGC
TTGCGGCGAGCCTCACAGGCAATGTCACGGCCATCAAGGCTCGCCGCAAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z3IR43

Antitoxin

Source ID Structure
AlphaFold DB A0A618JW87

References