Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 979483..980297 | Replicon | chromosome |
| Accession | NZ_CP075106 | ||
| Organism | Salmonella enterica strain CFSAN064276 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A623LUR5 |
| Locus tag | CBI76_RS04685 | Protein ID | WP_023243184.1 |
| Coordinates | 979483..980010 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | CBI76_RS04690 | Protein ID | WP_000855694.1 |
| Coordinates | 980007..980297 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CBI76_RS04655 (975685) | 975685..976083 | + | 399 | Protein_913 | cytoplasmic protein | - |
| CBI76_RS04660 (976274) | 976274..976513 | + | 240 | Protein_914 | hypothetical protein | - |
| CBI76_RS04665 (976670) | 976670..977338 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| CBI76_RS04670 (977365) | 977365..977859 | + | 495 | WP_000424947.1 | hypothetical protein | - |
| CBI76_RS04675 (978104) | 978104..978760 | - | 657 | WP_023243186.1 | protein-serine/threonine phosphatase | - |
| CBI76_RS04680 (978990) | 978990..979410 | + | 421 | Protein_918 | transposase | - |
| CBI76_RS04685 (979483) | 979483..980010 | - | 528 | WP_023243184.1 | GNAT family N-acetyltransferase | Toxin |
| CBI76_RS04690 (980007) | 980007..980297 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| CBI76_RS04695 (980567) | 980567..980767 | - | 201 | Protein_921 | IS3 family transposase | - |
| CBI76_RS04700 (981170) | 981170..981613 | - | 444 | WP_000715099.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| CBI76_RS04705 (982071) | 982071..982721 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| CBI76_RS04710 (982718) | 982718..984406 | + | 1689 | WP_023244646.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 979216..980767 | 1551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19121.98 Da Isoelectric Point: 9.0946
>T202804 WP_023243184.1 NZ_CP075106:c980010-979483 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T202804 NZ_CP099627:c186983-186579 [Paraburkholderia fungorum]
TTGAACGGCTATCTGCTGGACACGAACGTCATCCGCGACATGATCCGCTATCCGTCCGGAAAGGTGGCCACCCATATCGG
GCAAATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCCAGAAAGGGTTCCG
AAAAATTGCTGGCCAGAGTGGAAAGCCTGCTTGCGATCATTCCCGTGCTGCCGCTGGACGTGCCTGCTGACACCGAATAC
GGGGGTATTCGTGCAGAGCTTGAGATTGCTGGCCAGCCGATCGGTGCAAACGAGCTTCTGATCGCGGCTCATGCCTGTGC
GTTGGGGCTCACACTCGTGACTGACAACACGAAGGTGTTCAGCCGCATACGCGGTCTTGCGATCGAGAACTGGCTTGACC
GGTAG
TTGAACGGCTATCTGCTGGACACGAACGTCATCCGCGACATGATCCGCTATCCGTCCGGAAAGGTGGCCACCCATATCGG
GCAAATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCCAGAAAGGGTTCCG
AAAAATTGCTGGCCAGAGTGGAAAGCCTGCTTGCGATCATTCCCGTGCTGCCGCTGGACGTGCCTGCTGACACCGAATAC
GGGGGTATTCGTGCAGAGCTTGAGATTGCTGGCCAGCCGATCGGTGCAAACGAGCTTCTGATCGCGGCTCATGCCTGTGC
GTTGGGGCTCACACTCGTGACTGACAACACGAAGGTGTTCAGCCGCATACGCGGTCTTGCGATCGAGAACTGGCTTGACC
GGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT202804 WP_000855694.1 NZ_CP075106:c980297-980007 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT202804 NZ_CP099627:c187252-186980 [Paraburkholderia fungorum]
ATGCCCGTGCCCCCTCCTTCCGGCCGCCCCAGGGAGGCCAGACTGTTCCGCAACAACCGGAGTCAGGCGGTACGCATCCC
GGTCGAATTCGAGTTGCCGGGTGATCGCGTCCTGATCTATCGGGAGGGCGACAGGCTCATCATCGAGCCGGTGAAAACCC
CCGCGAACATCATCGAATTGCTGGATGCATGGAGACAGGAGCCACGGTTCGGACCTGACGACCAGTTTCCGGATATTGAG
GATGCGCCTCTTCAGCCGGAGGGCATACCTTGA
ATGCCCGTGCCCCCTCCTTCCGGCCGCCCCAGGGAGGCCAGACTGTTCCGCAACAACCGGAGTCAGGCGGTACGCATCCC
GGTCGAATTCGAGTTGCCGGGTGATCGCGTCCTGATCTATCGGGAGGGCGACAGGCTCATCATCGAGCCGGTGAAAACCC
CCGCGAACATCATCGAATTGCTGGATGCATGGAGACAGGAGCCACGGTTCGGACCTGACGACCAGTTTCCGGATATTGAG
GATGCGCCTCTTCAGCCGGAGGGCATACCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A623LUR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |