Detailed information of TA system TA202803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 832364..832989
• Replicon: chromosome
• Accession: NZ_CP075106
• Organism: Salmonella enterica strain CFSAN064276

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CBI76_RS04030
• Protein ID: WP_000911337.1
• Coordinates: 832591..832989 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M7S3S8
• Locus tag: CBI76_RS04025
• Protein ID: WP_000557549.1
• Coordinates: 832364..832591 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI76_RS03995 (827428)	827428..828526	+	1099	WP_010989230.1	peptide chain release factor 2	-
CBI76_RS04000 (828536)	828536..830053	+	1518	WP_000003339.1	lysine--tRNA ligase	-
CBI76_RS04005 (830129)	830129..830674	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
CBI76_RS04010 (830939)	830939..831697	+	759	WP_000244328.1	amidase activator ActS	-
CBI76_RS04020 (831943)	831943..832155	-	213	WP_024149321.1	endonuclease	-
CBI76_RS04025 (832364)	832364..832591	+	228	WP_000557549.1	toxin-antitoxin system antitoxin VapB	Antitoxin
CBI76_RS04030 (832591)	832591..832989	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CBI76_RS04035 (833795)	833795..834331	+	537	WP_001038500.1	STM3031 family outer membrane protein	-
CBI76_RS04040 (834378)	834378..835010	+	633	WP_000835264.1	YfdX family protein	-
CBI76_RS04045 (835729)	835729..836310	+	582	WP_023243212.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	832364..842167	9803

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T202803 WP_000911337.1 NZ_CP075106:832591-832989 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T202803 NZ_CP099625:3560363-3560659 [Paraburkholderia fungorum]
TTGGAAAAAAGTACGCCTCATTGCAAGCTGGCCGAGGTTCAAAGCCTGGCGCGTGCGGGGAACATCAGAATCACGAAATC
GGCCGTGATTGGAGCCGCGGCACTTGGCCTCGGACCCGCGGCAATCATCGAGACATTGCTGTCGCTCGAGCGCGGGAATT
TTCGAAAAAGCATGACCACGTACGCGGACCATCGGGTCTGGCAGGACGTCTACTGTGCCGTCACGGAAGCAGGCATGGTC
TATTTGAAATTGACGGTGATCGACGACGTTCTTGTCGTGTCATTCAAGGAGTGGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8514.51 Da
• Isoelectric Point: 5.0210

>AT202803 WP_000557549.1 NZ_CP075106:832364-832591 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT202803 NZ_CP099625:3560662-3561063 [Paraburkholderia fungorum]
ATGAAATGCCCGAACTGCGGCGCGGCCGAACTGGTGCGCGATACGCGCAATATGCGCTATGTCTACAAGGGCGAGACGGC
TGTATTCGAAGCCGTCACGGGTGACTATTGTCCGGCGTGCGACGAGGCGGTGCTCGACATCGACGAAGCCACACGCACCG
GGCAAATGATGCTGGCTTTCAACAAAGAGGTGAATGCCTCGCAAGTGGATCCTGCCTTCATTGCCGCTGTGCGCAAGAAG
CTCGATCTGGACCAGCGCGAGGCAGCGGAGATTTTCGGCGGGGGGGTGAACGCCTTTTCGCGCTACGAAAATGGCAAGAC
CCGGCCGCCGCTCGCTCTGATCAAACTGTTGAAAGTGCTGGACCGGCATCCGGAGCTGCTGGAAGAAGTCAGGGCGAGTT
GA

Structures

Antitoxin

• AlphaFold DB: A0A3V2Y5V5