Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 832364..832989 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CBI76_RS04030 Protein ID WP_000911337.1
Coordinates 832591..832989 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag CBI76_RS04025 Protein ID WP_000557549.1
Coordinates 832364..832591 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS03995 (827428) 827428..828526 + 1099 WP_010989230.1 peptide chain release factor 2 -
CBI76_RS04000 (828536) 828536..830053 + 1518 WP_000003339.1 lysine--tRNA ligase -
CBI76_RS04005 (830129) 830129..830674 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
CBI76_RS04010 (830939) 830939..831697 + 759 WP_000244328.1 amidase activator ActS -
CBI76_RS04020 (831943) 831943..832155 - 213 WP_024149321.1 endonuclease -
CBI76_RS04025 (832364) 832364..832591 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
CBI76_RS04030 (832591) 832591..832989 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
CBI76_RS04035 (833795) 833795..834331 + 537 WP_001038500.1 STM3031 family outer membrane protein -
CBI76_RS04040 (834378) 834378..835010 + 633 WP_000835264.1 YfdX family protein -
CBI76_RS04045 (835729) 835729..836310 + 582 WP_023243212.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 832364..842167 9803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T202803 WP_000911337.1 NZ_CP075106:832591-832989 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T202803 NZ_CP099625:3560363-3560659 [Paraburkholderia fungorum]
TTGGAAAAAAGTACGCCTCATTGCAAGCTGGCCGAGGTTCAAAGCCTGGCGCGTGCGGGGAACATCAGAATCACGAAATC
GGCCGTGATTGGAGCCGCGGCACTTGGCCTCGGACCCGCGGCAATCATCGAGACATTGCTGTCGCTCGAGCGCGGGAATT
TTCGAAAAAGCATGACCACGTACGCGGACCATCGGGTCTGGCAGGACGTCTACTGTGCCGTCACGGAAGCAGGCATGGTC
TATTTGAAATTGACGGTGATCGACGACGTTCTTGTCGTGTCATTCAAGGAGTGGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT202803 WP_000557549.1 NZ_CP075106:832364-832591 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT202803 NZ_CP099625:3560662-3561063 [Paraburkholderia fungorum]
ATGAAATGCCCGAACTGCGGCGCGGCCGAACTGGTGCGCGATACGCGCAATATGCGCTATGTCTACAAGGGCGAGACGGC
TGTATTCGAAGCCGTCACGGGTGACTATTGTCCGGCGTGCGACGAGGCGGTGCTCGACATCGACGAAGCCACACGCACCG
GGCAAATGATGCTGGCTTTCAACAAAGAGGTGAATGCCTCGCAAGTGGATCCTGCCTTCATTGCCGCTGTGCGCAAGAAG
CTCGATCTGGACCAGCGCGAGGCAGCGGAGATTTTCGGCGGGGGGGTGAACGCCTTTTCGCGCTACGAAAATGGCAAGAC
CCGGCCGCCGCTCGCTCTGATCAAACTGTTGAAAGTGCTGGACCGGCATCCGGAGCTGCTGGAAGAAGTCAGGGCGAGTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References