Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822604..823264 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag CBI76_RS03970 Protein ID WP_000244756.1
Coordinates 822851..823264 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CBI76_RS03965 Protein ID WP_000351186.1
Coordinates 822604..822870 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS03945 (818533) 818533..819966 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
CBI76_RS03950 (820124) 820124..820435 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
CBI76_RS03955 (820599) 820599..821258 + 660 WP_000250289.1 hemolysin III family protein -
CBI76_RS03960 (821374) 821374..822354 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
CBI76_RS03965 (822604) 822604..822870 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CBI76_RS03970 (822851) 822851..823264 + 414 WP_000244756.1 protein YgfX Toxin
CBI76_RS03975 (823317) 823317..823838 - 522 WP_001055885.1 flavodoxin FldB -
CBI76_RS03980 (823951) 823951..824847 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
CBI76_RS03985 (824871) 824871..825584 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CBI76_RS03990 (825590) 825590..827323 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202802 WP_000244756.1 NZ_CP075106:822851-823264 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202802 NZ_CP099625:c1860626-1859727 [Paraburkholderia fungorum]
ATGTCCGCAGTCCCGTCCCGTATCGCCGATAACGTCGATCAGAACGCTACGCTCGAAGCGCGCCTTGCACGCTTTCCGGC
GCAGCAGATCTGGCTCGCATCGCAACGTGCGGTGAGTTATCGCGAGGCGGATAGCGCAGCAAGCGACGCACTGCCTTTGG
TGCTGCTTCACGGTATCGGGTCGGGCGCGGCTTCGTGGGTACAACAGTTTGAAGTGCTGGGCGAGACGCGTTGTGTGCTG
GCGTGGGATGCACCGGGGTATGGCGCGTCGACCCCGGTAGAAGCCGATTCGCCCGCTGCAGGCGACTACGCAACGGTGCT
GAAAGAATGGCTCGACGCGCTCGGCATTGAGCGCTGTGTGCTGCTGGGGCATTCGCTTGGCGCGATCGTCGCCGGTGCGT
TTGCTGTGACGAATCCGCAGCTTGTGGCCGGTTTACTCCTGCTGTCGCCGGCTGGCGGATATGGCGCTTCGCCTGCGGAC
GTGCGCGAGAGCAAACGCAATCAGCGTCTCGCCATGATTAAGGAACTCGGCCCACAAGGTCTCGCTGAAAAACGCAGCAC
CAATATGTTGTCCGCGAACGCGAGCGATGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGGGTGATCCCACGTGGCT
ATGTTCAAGCAACACATCTGCTCGCGAACGCCGATCTCGCCAGCGATCTCGCGCGCTACAAAGGTCACATCAGCATCGCA
GTCGGCGCAGACGACGCTATCACGCCCCCCGAAGCCTGCGAGCGACTCGCCCTGACGGCCAGCACCAGGTTGCAGGTTGT
GCCGGGCGCGGGGCATGCCGGCTATATCGAAGCACCCACCGCGTACACCGCGATCATCGACACGTTCTGTCGCGCGAGCG
ACGGACAACGGAGCCAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202802 WP_000351186.1 NZ_CP075106:822604-822870 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202802 NZ_CP099625:c1859726-1858833 [Paraburkholderia fungorum]
ATGACGCCCGACACGATTAACGCCGAGCGCGACGCGGACGACGACCGCAACGACGCGGACGCCAGCAGCGAGATCAACTA
TCGCGTGCCGGGTCTGGAACGTGGTCTGAAGATACTGACCGAGTTTTCGCCGCGCGAGCCGGTTCTCGGCGCACCGGAAC
TATCGAAGCGCCTGAAGATTCCCCGCACAACGGTGTTCCGTCTGCTGCAAACACTCGAATCGCTCGGTTTTCTCGAGCGC
GCTGATAAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTTCGGCTCGGTTTCGAGTACCTGAGCTCGCTTGAACTGAC
CGATCTCGGTTTGCCGATCATCGAAGCCTTGCGCAACGACACCGGCCTCACCAGCCATATCGTGATTCGCGACGGACGCG
ATGTTGTGTTCGTCGCGAAGGCGCAAAGTCATGCGCCGATCTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGTCTGCCG
GCTTACGCAACGACGCACGGCCAGGTGCTGATGAGCGACATGACGCTCGACGAGTTGAAAAAGCTCTATCCCGAGCCGGA
ACTGGAACGCTTTACGAAGCAAACACCCGCCACCGTCGAGGAGTTGTACGAACGGGTTTGCGATGACGCGAGGCGCGGTT
ACGCGATCAGCGAGTCGTCGTTCGAACGCGGCATTTCCGTGGTGAGCGCGCCGGTTCGCAACGACACGGGCCGCATCGTC
GCGGTGATTACGACCACGATTCCGCGTCCCGAGATCGACGCTTCGCTGCTCGACAGCGGCCTGATCGACAAGGTTCGCCG
CGCGGCCGACGAACTCTCGCAGCGGCTCAATTATCGGCCGAAGGGTAGCGCGAACGCGGGCACGAAATACATGAAGGCAC
TGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References