Detailed information of TA system TA202801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 315808..316394
• Replicon: chromosome
• Accession: NZ_CP075106
• Organism: Salmonella enterica strain CFSAN064276

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q57IR9
• Locus tag: CBI76_RS01450
• Protein ID: WP_000174963.1
• Coordinates: 316026..316394 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: CBI76_RS01445
• Protein ID: WP_001522145.1
• Coordinates: 315808..316029 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI76_RS01420 (310829)	310829..311938	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
CBI76_RS01425 (311998)	311998..312924	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
CBI76_RS01430 (312921)	312921..314198	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
CBI76_RS01435 (314195)	314195..314962	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
CBI76_RS01440 (314964)	314964..315677	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
CBI76_RS01445 (315808)	315808..316029	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CBI76_RS01450 (316026)	316026..316394	+	369	WP_000174963.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
CBI76_RS01455 (316653)	316653..317969	+	1317	WP_000624747.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
CBI76_RS01460 (318074)	318074..318961	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
CBI76_RS01465 (318958)	318958..319803	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
CBI76_RS01470 (319805)	319805..320875	+	1071	WP_023243433.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	305587..321612	16025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13573.85 Da
• Isoelectric Point: 6.7252

>T202801 WP_000174963.1 NZ_CP075106:316026-316394 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T202801 NZ_CP099625:c82269-81970 [Paraburkholderia fungorum]
ATGTTGAAAATCCGCACCACCGAGACATTTGACGCCTGGTTCGACGGCTTGAAAGACCGGATCGCGAGGCGCCGCATTCA
GGCCCGCATCGACCGTCTGGCGATGGGCAACCCCGGCGACACGAACTCCGCCGGTGCGCCAATTATCGAACTGCGGATCG
ATCACGGTCCCGGCTATCGCGTCTACTACGTGCAGCGCGGCGCAGTGCTGGTGATCCTGCTGTGTGGTGGTGACAAGTCG
ACTCAACCCGCAGATATCAAAGCCGCACACAAGATGCTGGCGAACCTTGAATCGGAGTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT202801 WP_001522145.1 NZ_CP075106:315808-316029 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT202801 NZ_CP099625:c81966-81667 [Paraburkholderia fungorum]
ATGGGAAAAATCAAAACCCGGCCATGGGATTCGGCCGAACACCTGAAGACCGAAGCGGACATGGCAGAGTATTTCGAGGC
CTGTCTGGTCGAAGGCGGCGACGATCCTGCATTCCTCGCGCATGCGTTGGGCGTGATCGCGCGTGCGCGCGGCATGGCGC
AACTCGCCCGCGATACCGGGATCTCGCGCGAGGGCTTGTACAAGGCACTCTCCGAAGATGGCAACCCCAGCTTCGCGACG
ATCATCAAGGTGATCCGCGCTCTTGGTCTGGAGTTGCACGCGGCGCCTGCTCACGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5H6KCD5