Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 211689..212449 Replicon chromosome
Accession NZ_CP075106
Organism Salmonella enterica strain CFSAN064276

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag CBI76_RS00990 Protein ID WP_000533909.1
Coordinates 211964..212449 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag CBI76_RS00985 Protein ID WP_000965886.1
Coordinates 211689..211976 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBI76_RS00965 (207094) 207094..208005 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
CBI76_RS00970 (208015) 208015..210084 + 2070 WP_020437730.1 glycine--tRNA ligase subunit beta -
CBI76_RS00975 (210474) 210474..210872 + 399 Protein_194 IS3 family transposase -
CBI76_RS00980 (211044) 211044..211511 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
CBI76_RS00985 (211689) 211689..211976 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
CBI76_RS00990 (211964) 211964..212449 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
CBI76_RS00995 (212820) 212820..213359 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
CBI76_RS01000 (213534) 213534..213746 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CBI76_RS01005 (214034) 214034..214324 - 291 WP_000455790.1 HTH-type transcriptional regulator -
CBI76_RS01010 (214763) 214763..215473 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CBI76_RS01015 (215523) 215523..216497 - 975 WP_000804693.1 glyoxylate/hydroxypyruvate reductase GhrB -
CBI76_RS01020 (216716) 216716..217378 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202800 WP_000533909.1 NZ_CP075106:211964-212449 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202800 NZ_CP099625:c81966-81667 [Paraburkholderia fungorum]
ATGGGAAAAATCAAAACCCGGCCATGGGATTCGGCCGAACACCTGAAGACCGAAGCGGACATGGCAGAGTATTTCGAGGC
CTGTCTGGTCGAAGGCGGCGACGATCCTGCATTCCTCGCGCATGCGTTGGGCGTGATCGCGCGTGCGCGCGGCATGGCGC
AACTCGCCCGCGATACCGGGATCTCGCGCGAGGGCTTGTACAAGGCACTCTCCGAAGATGGCAACCCCAGCTTCGCGACG
ATCATCAAGGTGATCCGCGCTCTTGGTCTGGAGTTGCACGCGGCGCCTGCTCACGCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202800 WP_000965886.1 NZ_CP075106:211689-211976 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202800 NZ_CP099625:c82269-81970 [Paraburkholderia fungorum]
ATGTTGAAAATCCGCACCACCGAGACATTTGACGCCTGGTTCGACGGCTTGAAAGACCGGATCGCGAGGCGCCGCATTCA
GGCCCGCATCGACCGTCTGGCGATGGGCAACCCCGGCGACACGAACTCCGCCGGTGCGCCAATTATCGAACTGCGGATCG
ATCACGGTCCCGGCTATCGCGTCTACTACGTGCAGCGCGGCGCAGTGCTGGTGATCCTGCTGTGTGGTGGTGACAAGTCG
ACTCAACCCGCAGATATCAAAGCCGCACACAAGATGCTGGCGAACCTTGAATCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References