Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3676360..3676978 Replicon chromosome
Accession NZ_CP075062
Organism Escherichia coli strain EC_J_9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H4F96_RS17890 Protein ID WP_001291435.1
Coordinates 3676760..3676978 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H4F96_RS17885 Protein ID WP_000344800.1
Coordinates 3676360..3676734 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F96_RS17875 (3671449) 3671449..3672642 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H4F96_RS17880 (3672665) 3672665..3675814 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H4F96_RS17885 (3676360) 3676360..3676734 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H4F96_RS17890 (3676760) 3676760..3676978 + 219 WP_001291435.1 HHA domain-containing protein Toxin
H4F96_RS17895 (3677150) 3677150..3677701 + 552 WP_000102564.1 maltose O-acetyltransferase -
H4F96_RS17900 (3677817) 3677817..3678287 + 471 WP_000136192.1 YlaC family protein -
H4F96_RS17905 (3678451) 3678451..3680001 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H4F96_RS17910 (3680043) 3680043..3680396 - 354 WP_000878141.1 DUF1428 family protein -
H4F96_RS17920 (3680775) 3680775..3681086 + 312 WP_000409911.1 MGMT family protein -
H4F96_RS17925 (3681117) 3681117..3681689 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T202781 WP_001291435.1 NZ_CP075062:3676760-3676978 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202781 NZ_CP099609:2774099-2774380 [Pseudomonas moraviensis]
ATGACCTATGAGCTGGAGTTTTCTGATAAGGCTTGGAGAGAGTGGGGGAAACTCGGGTCGGAACTCAGGGAGCAGTTCAA
AAACAAACTTTTGGAGAGGCTGGCAAATCCGCACGTTCCGGCGGCTCGCCTGAAAGGGTTGAGTAACGCCTATAAAATCA
AGCTTCGAAGCGCTGGATATCGGTTGGTCTATCGGGTAAGGGATGAGGTGCTGGTCGTTACGGTGATAGCGGTCGGGAAA
CGGCAGGGTGGTGACGTTTACAGGCAGGCTCTCAAACGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT202781 WP_000344800.1 NZ_CP075062:3676360-3676734 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT202781 NZ_CP099609:2773861-2774109 [Pseudomonas moraviensis]
ATGACGCACATCGTTCTTTCTCATGTCGTAGCGAGTATTTCCGAATTGAAAAAAAATCCTATGGGTACAGTCGCTGCTGG
TGGAGGCCGGTCAGTGGCGATCCTTAATCGAAACGAACCGGCTTTTTATTGCGTGCCCGCCAAAGAATACGAGGCAATGA
TGGAGCGCCTTGATGATCTGGAACTGATCGCCCTCTGTAGGGAGCGAGAAAACGATCCGACCATCAAGGTATCCATTGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References