Detailed information of TA system TA202779

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2952326..2953171
• Replicon: chromosome
• Accession: NZ_CP075062
• Organism: Escherichia coli strain EC_J_9

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: H4F96_RS14440
• Protein ID: WP_000854686.1
• Coordinates: 2952326..2952709 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1M2U6P5
• Locus tag: H4F96_RS14445
• Protein ID: WP_001774606.1
• Coordinates: 2952803..2953171 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4F96_RS14400 (2947328)	2947328..2947819	-	492	WP_001471346.1	DUF1097 domain-containing protein	-
H4F96_RS14405 (2947921)	2947921..2948475	-	555	WP_001001902.1	molecular chaperone YcdY	-
H4F96_RS14410 (2948499)	2948499..2949236	-	738	WP_000283664.1	zinc-binding phosphatase	-
H4F96_RS14415 (2949291)	2949291..2950229	-	939	WP_001471345.1	glyoxylate/hydroxypyruvate reductase GhrA	-
H4F96_RS14425 (2950700)	2950700..2951542	-	843	WP_001274547.1	DUF4942 domain-containing protein	-
H4F96_RS14430 (2951627)	2951627..2951824	-	198	WP_000839253.1	DUF957 domain-containing protein	-
H4F96_RS14435 (2951841)	2951841..2952329	-	489	WP_001054233.1	DUF5983 family protein	-
H4F96_RS14440 (2952326)	2952326..2952709	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
H4F96_RS14445 (2952803)	2952803..2953171	-	369	WP_001774606.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
H4F96_RS14450 (2953221)	2953221..2953865	-	645	WP_213190754.1	antitoxin of toxin-antitoxin stability system	-
H4F96_RS14455 (2953884)	2953884..2954105	-	222	WP_000692298.1	DUF987 domain-containing protein	-
H4F96_RS14460 (2954168)	2954168..2954644	-	477	WP_001186726.1	RadC family protein	-
H4F96_RS14465 (2954660)	2954660..2955145	-	486	WP_213190755.1	antirestriction protein	-
H4F96_RS14470 (2955237)	2955237..2956055	-	819	WP_001234732.1	DUF932 domain-containing protein	-
H4F96_RS14475 (2956155)	2956155..2956388	-	234	WP_001119719.1	DUF905 family protein	-
H4F96_RS14480 (2956467)	2956467..2956921	-	455	Protein_2848	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	csgB / csgD / csgE / csgF / csgG	2943710..2988851	45141

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T202779 WP_000854686.1 NZ_CP075062:c2952709-2952326 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T202779 NZ_CP099609:c1760198-1759623 [Pseudomonas moraviensis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTCTTATATCCGGCCCCTTTGAGAGACTTCCTTATGTGGCT
CGCGTTGTCTGGGCTGTATCGAGCTCGCTGGACTCAGGAAATACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGATGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGTCACCTCGCGCCATATGGCATCGAAGCTCAACACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTTGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTAAAGGCGTTAGGTAACTA
TCGAGCGATTCTCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13593.31 Da
• Isoelectric Point: 5.8746

>AT202779 WP_001774606.1 NZ_CP075062:c2953171-2952803 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT202779 NZ_CP099609:c1760662-1760195 [Pseudomonas moraviensis]
ATGCCCACTCCAATTCCTTCCACTACAAATTTGCCAGTTGAACGCGAAGTCAAAGCCGCGATTGAAGGCCAGCGCACCCT
CACCGCTTTCCTCGCCACAGGTTTCGATACCCAGCGAATCCAGATTTTTGATGAGCAGAATGAAGCCCACAGCGTCGAGC
TGCCAACGTCGGCATTGCGCTTGCTGAGCGATATCCTCGCAGCGCTGGCGGAGGGCAACGCTGTGAAGGTCGTGCCGATC
CATGCCGAGCTGACCACTCAAGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGAGGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1M2U6P5