Detailed information of TA system TA202778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2433225..2434321
• Replicon: chromosome
• Accession: NZ_CP075062
• Organism: Escherichia coli strain EC_J_9

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8S7TJ53
• Locus tag: H4F96_RS11870
• Protein ID: WP_063112742.1
• Coordinates: 2433491..2434321 (+)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H4F96_RS11865
• Protein ID: WP_001296726.1
• Coordinates: 2433225..2433491 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4F96_RS11865 (2433225)	2433225..2433491	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
H4F96_RS11870 (2433491)	2433491..2434321	+	831	WP_063112742.1	HipA N-terminal domain-containing protein	Toxin
H4F96_RS11875 (2434633)	2434633..2434841	+	209	Protein_2330	AraC family transcriptional regulator	-
H4F96_RS11880 (2435273)	2435273..2435836	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
H4F96_RS11885 (2436196)	2436196..2436906	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2433225..2448820	15595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (115-237)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 31181.99 Da
• Isoelectric Point: 10.0235

>T202778 WP_063112742.1 NZ_CP075062:2433491-2434321 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 831 bp

>T202778 NZ_CP099609:c291367-291053 [Pseudomonas moraviensis]
ATGATTTTTATTGAGACTTCAGTCTTTACCCGCCGAGTAAGAGAGTTACTGGACGACGATGCCTACGCCACCTTTCAAAA
GCAGCTGGTCGCAGACCCGTCCATTGGCGATGTAATCGAAGGGACCGGGGGGGTGCGTAAAGCACGAGTCGCCTCCAAAG
GCCACGGTAAACGAGGAGGAGCACGGGTCATCTACTACCACTTCGTTTCAGCATCACAGATCGCGTTGTTGATGATTTAC
TCAAAAAATGAGCAGCAGGATCTTACTCATGACGAACGGAAAGCACTGAAGGCCATGATTGGAAACTGGAGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT202778 WP_001296726.1 NZ_CP075062:2433225-2433491 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT202778 NZ_CP099609:c291050-290763 [Pseudomonas moraviensis]
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGCGTGCAGGAAATGGATGAGATTCTTCGGGGTGAAAAAAAACCTTCCCG
CGAATTTCATGTGGATGCATTACAGGTTAAACAGATTCGCAAAGCGACGGGAATGACGCAGGCAAAGTTCGCAGCCTTGA
TTGATGTCCAGCTCGGGACGTTACGGAATTGGGAGCAAGGTCGTCGTCAGCCGACTGGCCCGGCTAAAGCACTGCTCAAG
GCCATTCATAACGATCCTGTCCATGTGCTCAGTGCACTTGCTGATTGA