Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1390930..1391555 Replicon chromosome
Accession NZ_CP075062
Organism Escherichia coli strain EC_J_9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H4F96_RS06745 Protein ID WP_000911330.1
Coordinates 1391157..1391555 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H4F96_RS06740 Protein ID WP_000450524.1
Coordinates 1390930..1391157 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F96_RS06715 (1386733) 1386733..1387203 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H4F96_RS06720 (1387203) 1387203..1387775 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H4F96_RS06725 (1387921) 1387921..1388799 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H4F96_RS06730 (1388816) 1388816..1389850 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
H4F96_RS06735 (1390063) 1390063..1390776 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H4F96_RS06740 (1390930) 1390930..1391157 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H4F96_RS06745 (1391157) 1391157..1391555 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
H4F96_RS06750 (1391702) 1391702..1392565 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H4F96_RS06755 (1392580) 1392580..1394595 + 2016 WP_063112794.1 tRNA cytosine(34) acetyltransferase TmcA -
H4F96_RS06760 (1394669) 1394669..1395367 + 699 WP_000679823.1 esterase -
H4F96_RS06765 (1395477) 1395477..1395677 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T202768 WP_000911330.1 NZ_CP075062:1391157-1391555 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T202768 NZ_CP099608:c1470856-1470677 [Pseudomonas moraviensis]
GTGAATAGCCGTTTTTTAATCGGACAACTCGTGGCAGACGGGTGGTTTCTGGTGCGCATCCGGGGCAGCCATCATCACTT
CAAGCATCCAACCAAACCTGGACTGGTAACAGTGCCGCATCCGAAAAAGGATCTGCTCAAAAAAACGGCCGTCAGTATTT
TGCAACAGGCCATGCTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT202768 WP_000450524.1 NZ_CP075062:1390930-1391157 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT202768 NZ_CP099608:c1470641-1470234 [Pseudomonas moraviensis]
ATGCTTTACCCGATTGCGATTTCAATAGGCGACGAGGAACACGCCTGGGGAGTTGAGGTGCCGGACCTTCCCGGTTGTTT
TTCTGCCGGCGAAGACCTTGATGACGCCGTCGCCATGGCGCGCGAGGCGATCGAAGGTCATTTCGAAATTCTGGCAGACG
ACGATGCGCCGATTCCACCGGCCAGCAAATTGAGCCTGCATGTCGCCAATCCGAAGTACGCCGGATGTGCGTGGGCGGTA
GTGGATATCGACGTAGTCAAATACCTAGGCAAAGCACAGAAGCTCAACATCACTCTGCCAGGGCATTTGCTCAATCGCAT
TGATGAATACGTCTTGCATCATCCAGAGGAGAAAAGCCGATCGGGGTTTCTGGCTTCGGCGGCGTTGAAAGTTTTGCAGC
AAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References