Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 774884..775719 | Replicon | chromosome |
| Accession | NZ_CP075062 | ||
| Organism | Escherichia coli strain EC_J_9 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1C0Y405 |
| Locus tag | H4F96_RS03750 | Protein ID | WP_001774607.1 |
| Coordinates | 774884..775261 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M2U6P5 |
| Locus tag | H4F96_RS03755 | Protein ID | WP_001774606.1 |
| Coordinates | 775351..775719 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4F96_RS03720 (770292) | 770292..771269 | + | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| H4F96_RS03725 (771266) | 771266..772444 | + | 1179 | WP_000094973.1 | type II secretion system protein GspL | - |
| H4F96_RS03730 (772446) | 772446..772982 | + | 537 | WP_000942799.1 | GspM family type II secretion system protein YghD | - |
| H4F96_RS03735 (773263) | 773263..774105 | - | 843 | WP_040235333.1 | DUF4942 domain-containing protein | - |
| H4F96_RS03740 (774190) | 774190..774387 | - | 198 | WP_032152719.1 | DUF957 domain-containing protein | - |
| H4F96_RS03745 (774399) | 774399..774887 | - | 489 | WP_001774608.1 | DUF5983 family protein | - |
| H4F96_RS03750 (774884) | 774884..775261 | - | 378 | WP_001774607.1 | TA system toxin CbtA family protein | Toxin |
| H4F96_RS03755 (775351) | 775351..775719 | - | 369 | WP_001774606.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| H4F96_RS03760 (775769) | 775769..776413 | - | 645 | WP_001774605.1 | hypothetical protein | - |
| H4F96_RS03765 (776432) | 776432..776653 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| H4F96_RS03770 (776716) | 776716..777192 | - | 477 | WP_001297237.1 | RadC family protein | - |
| H4F96_RS03775 (777208) | 777208..777687 | - | 480 | WP_032152717.1 | antirestriction protein | - |
| H4F96_RS03780 (778026) | 778026..778844 | - | 819 | WP_016238867.1 | DUF932 domain-containing protein | - |
| H4F96_RS03785 (778943) | 778943..779176 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| H4F96_RS03790 (779182) | 779182..779859 | - | 678 | WP_144745839.1 | hypothetical protein | - |
| H4F96_RS03795 (780007) | 780007..780687 | - | 681 | WP_032082725.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 739906..840061 | 100155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14218.20 Da Isoelectric Point: 7.8045
>T202764 WP_001774607.1 NZ_CP075062:c775261-774884 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T202764 NZ_CP099602:3113019-3113309 [Pseudomonas siliginis]
ATGGCTGAATACCGACTTACCCCCGCCGCCGAAGCGGATCTTGAGGCTATCTGGACCTATACAGCTCAACAATGGGGGTT
GGATCAGGCCAATCGCTACATCGACATCCTGACTGAGTCTTTCGAGCAGTTGGCTGATCGTCCCAAAACAGCACCCGCAT
GCGACGCTATCCGCCCCGGTTACCGACGCTGCAGCGTGGAGAGTCACATGATTTATTTTCGAATCACCGCCTATGGGATC
GCGATAATCAGAATCTTGCATGACCGGATGGAGGCGCAGCGTAATCTCTAA
ATGGCTGAATACCGACTTACCCCCGCCGCCGAAGCGGATCTTGAGGCTATCTGGACCTATACAGCTCAACAATGGGGGTT
GGATCAGGCCAATCGCTACATCGACATCCTGACTGAGTCTTTCGAGCAGTTGGCTGATCGTCCCAAAACAGCACCCGCAT
GCGACGCTATCCGCCCCGGTTACCGACGCTGCAGCGTGGAGAGTCACATGATTTATTTTCGAATCACCGCCTATGGGATC
GCGATAATCAGAATCTTGCATGACCGGATGGAGGCGCAGCGTAATCTCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.31 Da Isoelectric Point: 5.8746
>AT202764 WP_001774606.1 NZ_CP075062:c775719-775351 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT202764 NZ_CP099602:3112781-3113026 [Pseudomonas siliginis]
ATGGCTACCGTACGCAAAACCATAACCGTGACTGACCAGCAAGACCATTGGATCAAAGCTCAAATAGAAGCGGGACATTA
CACCAACGACAGCGAATATATCCGCGATTTGATCCGTCGAGAGCAAGAGCGAAACGCTGAACTGGAAACCGTCCGCGCAG
CCCTTCGAGAAGGAGAATCCAGTGGTGCCCCCCGGCCTTTCGATGCTGATGCTTTCAAAAAGAGAATGTTGAGGGCGCAT
GGCTGA
ATGGCTACCGTACGCAAAACCATAACCGTGACTGACCAGCAAGACCATTGGATCAAAGCTCAAATAGAAGCGGGACATTA
CACCAACGACAGCGAATATATCCGCGATTTGATCCGTCGAGAGCAAGAGCGAAACGCTGAACTGGAAACCGTCCGCGCAG
CCCTTCGAGAAGGAGAATCCAGTGGTGCCCCCCGGCCTTTCGATGCTGATGCTTTCAAAAAGAGAATGTTGAGGGCGCAT
GGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1C0Y405 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M2U6P5 |