Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4688885..4689552 | Replicon | chromosome |
| Accession | NZ_CP075061 | ||
| Organism | Escherichia coli strain TCM_B_2 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | E1IS66 |
| Locus tag | H4F95_RS25680 | Protein ID | WP_000856973.1 |
| Coordinates | 4689232..4689552 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | E1IS67 |
| Locus tag | H4F95_RS25675 | Protein ID | WP_000052843.1 |
| Coordinates | 4688885..4689211 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4F95_RS25650 (4684397) | 4684397..4685086 | + | 690 | WP_000115588.1 | WYL domain-containing protein | - |
| H4F95_RS25655 (4685148) | 4685148..4686158 | + | 1011 | WP_001348677.1 | hypothetical protein | - |
| H4F95_RS25660 (4686397) | 4686397..4687574 | + | 1178 | WP_085968792.1 | IS3 family transposase | - |
| H4F95_RS25665 (4687596) | 4687596..4688333 | + | 738 | Protein_4412 | DUF932 domain-containing protein | - |
| H4F95_RS25670 (4688402) | 4688402..4688872 | + | 471 | WP_001275770.1 | DNA repair protein RadC | - |
| H4F95_RS25675 (4688885) | 4688885..4689211 | + | 327 | WP_000052843.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H4F95_RS25680 (4689232) | 4689232..4689552 | + | 321 | WP_000856973.1 | TA system toxin CbtA family protein | Toxin |
| H4F95_RS26540 (4689761) | 4689761..4689922 | + | 162 | Protein_4416 | RhuM family protein | - |
| H4F95_RS25685 (4690319) | 4690319..4691503 | + | 1185 | WP_001172876.1 | sugar efflux transporter | - |
| H4F95_RS25690 (4691614) | 4691614..4692537 | + | 924 | WP_000535971.1 | carboxylate/amino acid/amine transporter | - |
| H4F95_RS25695 (4692541) | 4692541..4693359 | - | 819 | WP_000779426.1 | lipoprotein NlpA | - |
| H4F95_RS25700 (4693581) | 4693581..4693874 | + | 294 | WP_000805509.1 | protein YicS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12080.87 Da Isoelectric Point: 5.5873
>T202761 WP_000856973.1 NZ_CP075061:4689232-4689552 [Escherichia coli]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL
Download Length: 321 bp
>T202761 NZ_CP099602:c1785814-1785239 [Pseudomonas siliginis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTTTTATATCCGGCCCCTCTAAGAGATTTCCTGATGTGGCT
CGCGTTGTCAGGGCTGTATCGGGCTCGCTGGACTCAGGAAGTACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGACGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACACTGCCTGATGAGAACGATCGCCATGTTCTAGCGGCCGCAATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTACCCACCCGTCACCTCGCGCCATACGGCATTGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTCCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACG
CCCAATGTGGAGGTGGACAAATATCTCGGCTTTCTCCAACGGCAAGGATTGGTCGAGTCGGTAAAGGCGTTAGGTCACTA
TCGTGCGATTCTCTGA
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTTTTATATCCGGCCCCTCTAAGAGATTTCCTGATGTGGCT
CGCGTTGTCAGGGCTGTATCGGGCTCGCTGGACTCAGGAAGTACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGACGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACACTGCCTGATGAGAACGATCGCCATGTTCTAGCGGCCGCAATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTACCCACCCGTCACCTCGCGCCATACGGCATTGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTCCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACG
CCCAATGTGGAGGTGGACAAATATCTCGGCTTTCTCCAACGGCAAGGATTGGTCGAGTCGGTAAAGGCGTTAGGTCACTA
TCGTGCGATTCTCTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12305.01 Da Isoelectric Point: 6.3620
>AT202761 WP_000052843.1 NZ_CP075061:4688885-4689211 [Escherichia coli]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR
Download Length: 327 bp
>AT202761 NZ_CP099602:c1786278-1785811 [Pseudomonas siliginis]
ATGACCACCGCTACTCCATCTGCCATCAATCTGCCCGTCGAACGTGAGGTCAAAGCCGCGATTGAAGGCCAGCGCGCCCT
GAGCGCCTTCCTCACAACCGCTTTTGAAACTCAGCGAATCCAGATTTTTGATGAACAGAACGAAGCCCACAGCGTCGAGC
TGCCAACATCGGCGTTGCGCTTGCTGAGCGATATCCTCGCGGCGCTGGCGCAGGGCAACGCGGTGAAGGTGGTACCGATC
CACGCGGAGCTGACCACGCAGGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCTGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGATGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
ATGACCACCGCTACTCCATCTGCCATCAATCTGCCCGTCGAACGTGAGGTCAAAGCCGCGATTGAAGGCCAGCGCGCCCT
GAGCGCCTTCCTCACAACCGCTTTTGAAACTCAGCGAATCCAGATTTTTGATGAACAGAACGAAGCCCACAGCGTCGAGC
TGCCAACATCGGCGTTGCGCTTGCTGAGCGATATCCTCGCGGCGCTGGCGCAGGGCAACGCGGTGAAGGTGGTACCGATC
CACGCGGAGCTGACCACGCAGGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCTGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGATGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A345ENE3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A345ENE4 |