202759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3859654..3860308 Replicon chromosome
Accession NZ_CP075061
Organism Escherichia coli strain TCM_B_2

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag H4F95_RS21605 Protein ID WP_000244772.1
Coordinates 3859654..3860061 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H4F95_RS21610 Protein ID WP_000354046.1
Coordinates 3860042..3860308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F95_RS21585 (3855611) 3855611..3857344 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
H4F95_RS21590 (3857350) 3857350..3858060 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H4F95_RS21595 (3858085) 3858085..3858981 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H4F95_RS21600 (3859093) 3859093..3859614 + 522 WP_001055874.1 flavodoxin FldB -
H4F95_RS21605 (3859654) 3859654..3860061 - 408 WP_000244772.1 protein YgfX Toxin
H4F95_RS21610 (3860042) 3860042..3860308 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H4F95_RS21615 (3860551) 3860551..3861531 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H4F95_RS21620 (3861608) 3861608..3862267 - 660 WP_000250274.1 hemolysin III family protein -
H4F95_RS21625 (3862431) 3862431..3862742 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H4F95_RS21630 (3862787) 3862787..3864220 + 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
H4F95_RS21635 (3864277) 3864277..3865020 - 744 WP_000951940.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T202759 WP_000244772.1 NZ_CP075061:c3860061-3859654 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T202759 NZ_CP099602:c322064-321666 [Pseudomonas siliginis]
ATGATCAAGTACATGCTGGATACAAATATCTGCATCTTCACCATCAAGAACAAACCACAAATTGTCCGGGAAGCCTTCAA
TCGACATTCCGGGCAGTTGTGCATCAGCGCTATCACGCTTATGGAGCTTATTTACGGTGCTGAAAAGTCGGCGGCCCCGG
AGAAAAATCTGGCAATTGTTGAAGGATTTGTCGCGCGACTGGATGTCTTGCCTTTCGATAACGACGCAGCCGCACAGGCC
GGGATGGTTCGATCTGAACTCGCGAAGGCTGGAACGCCGATCGGGCCATACGACCAAATGATCGCTGGCCACGCACGCTC
ACTTGGACTCATTGTAGTGACGAACAACGTACGGGAGTTTGAACGCGTTTCCGGTTTGCGAATCGAGGACTGGGTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT202759 WP_000354046.1 NZ_CP075061:c3860308-3860042 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202759 NZ_CP099602:c322294-322064 [Pseudomonas siliginis]
ATGGAGCAGACCACAATTTTCATGAGCAACAGAAGTCAGGCAGTCCGACTGCCAAAGGCAGTTGCGATGCCCGGCGACGT
TAAACGAGTGGAAGTCATCGCGATTGGCAGAACACGCGTCATTACGCCTGCTGGAGAAAGCTGGGATAGCTGGTTTGATG
GCGACAGCGTCAGCCCTGATTTCATGGCTAACCGTGAGCAACCCACTGAACAGGAGCGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References