Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1255307..1255925 | Replicon | chromosome |
Accession | NZ_CP075061 | ||
Organism | Escherichia coli strain TCM_B_2 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | H4F95_RS09085 | Protein ID | WP_001291435.1 |
Coordinates | 1255307..1255525 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | H4F95_RS09090 | Protein ID | WP_000344800.1 |
Coordinates | 1255551..1255925 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H4F95_RS09050 (1250596) | 1250596..1251168 | + | 573 | WP_000779839.1 | YbaY family lipoprotein | - |
H4F95_RS09055 (1251199) | 1251199..1251510 | - | 312 | WP_000409911.1 | MGMT family protein | - |
H4F95_RS09065 (1251889) | 1251889..1252242 | + | 354 | WP_000878141.1 | DUF1428 family protein | - |
H4F95_RS09070 (1252284) | 1252284..1253834 | - | 1551 | WP_001299455.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
H4F95_RS09075 (1253998) | 1253998..1254468 | - | 471 | WP_000136192.1 | YlaC family protein | - |
H4F95_RS09080 (1254584) | 1254584..1255135 | - | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
H4F95_RS09085 (1255307) | 1255307..1255525 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
H4F95_RS09090 (1255551) | 1255551..1255925 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
H4F95_RS09095 (1256471) | 1256471..1259620 | - | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
H4F95_RS09100 (1259643) | 1259643..1260836 | - | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T202747 WP_001291435.1 NZ_CP075061:c1255525-1255307 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T202747 NZ_CP099600:3258371-3258592 [Pseudomonas siliginis]
ATCGAATACGTAGAACAACGCAACACCGTCGCTTCAGTTGCACTGCACCAAAAGCTCAGCGCCGCAGCGCGAAGGCTTTC
CTGGATACCGCATGGTTTCCGCTCCGGCCGAATACCGGGCACTCGCGAAATGGTCATCAACTCGAATTATTTACTGGTCT
ATCAGGTGACAGACCACATCAAAATTCTGACCGTGTTGCACGCCCGTAAAAAATATCCATAA
ATCGAATACGTAGAACAACGCAACACCGTCGCTTCAGTTGCACTGCACCAAAAGCTCAGCGCCGCAGCGCGAAGGCTTTC
CTGGATACCGCATGGTTTCCGCTCCGGCCGAATACCGGGCACTCGCGAAATGGTCATCAACTCGAATTATTTACTGGTCT
ATCAGGTGACAGACCACATCAAAATTCTGACCGTGTTGCACGCCCGTAAAAAATATCCATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT202747 WP_000344800.1 NZ_CP075061:c1255925-1255551 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT202747 NZ_CP099600:3258139-3258333 [Pseudomonas siliginis]
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGGATTACGATCTTTGGTATCGCGC
CAAGGTACAAGCCGCACTTGATGATCCACGTCCGCCTATCCCCCACGATGAGGCAATGGTGCTGCTAGGTCAGATGCTGG
AAGAGAGACGCAAGAATCGACGCGCTGCCGGTTAG
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGGATTACGATCTTTGGTATCGCGC
CAAGGTACAAGCCGCACTTGATGATCCACGTCCGCCTATCCCCCACGATGAGGCAATGGTGCTGCTAGGTCAGATGCTGG
AAGAGAGACGCAAGAATCGACGCGCTGCCGGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |