Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 517657..518252 Replicon chromosome
Accession NZ_CP075061
Organism Escherichia coli strain TCM_B_2

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H4F95_RS05560 Protein ID WP_000239579.1
Coordinates 517902..518252 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H4F95_RS05555 Protein ID WP_001223208.1
Coordinates 517657..517908 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F95_RS05545 (513321) 513321..517100 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
H4F95_RS05550 (517103) 517103..517444 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H4F95_RS05555 (517657) 517657..517908 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H4F95_RS05560 (517902) 517902..518252 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H4F95_RS05565 (518332) 518332..518862 - 531 WP_000055072.1 inorganic diphosphatase -
H4F95_RS05570 (519172) 519172..520128 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H4F95_RS05575 (520438) 520438..521940 + 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
H4F95_RS05580 (521954) 521954..522976 + 1023 WP_024198507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T202744 WP_000239579.1 NZ_CP075061:517902-518252 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T202744 NZ_CP099600:176826-177107 [Pseudomonas siliginis]
ATGACTTATAAGCTTGAGTTTCTGCCGTCTGCGCACAAAGAGTGGAACAAGCTGGGTCATACATTGCGGGAGCAGTTCAA
AAAGAAGCTGGGTGAGAGGCTGAAGCTTCCCAGAATCCCGGCTGACGCCCTCCACGGCATGCCCGACTGCTACAAAATCA
AACTCAAAGCCTCGGGATATCGATTGGTTTACCAAGTCATCGACGAACGAGTCGTGGTTTCCGTGCTAGCGGTTGGCAAG
CGCGAACGCAACAGCGTTTACGATGCTGCCAGGAACCGTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT202744 WP_001223208.1 NZ_CP075061:517657-517908 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT202744 NZ_CP099600:176591-176836 [Pseudomonas siliginis]
ATGCAAAGCGTTCTCGCCGATATGGCTGTCAGTGTCTCTGAACTGAAGAAAAATCCTACTGCCGTGTTGAACGGTGCACA
TGGGGGGGCCGTCGCTGTCCTCAACCACAATCGCGTCATGGGCTATATGGTGCCGGCCGAAGTTTATGAAGCAATGATGG
AGCGGCTTGATGATCTTGAGCTGGCTGACATTGTTCGTTCCCGCCTCCACGAAACGCCCATTTCGGTAAGCCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References