Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
Location | 52348..52949 | Replicon | plasmid pCTX_B2_4 |
Accession | NZ_CP075059 | ||
Organism | Escherichia coli strain TCM_B_2 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | H4F95_RS02500 | Protein ID | WP_089527475.1 |
Coordinates | 52348..52728 (-) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | H4F95_RS02505 | Protein ID | WP_072649184.1 |
Coordinates | 52728..52949 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H4F95_RS26295 | 47451..47570 | - | 120 | WP_071527722.1 | ash family protein | - |
H4F95_RS02475 (H4F95_02475) | 47792..49276 | - | 1485 | WP_155053612.1 | terminase | - |
H4F95_RS02480 (H4F95_02480) | 49276..50469 | - | 1194 | WP_000219605.1 | terminase | - |
H4F95_RS02485 (H4F95_02485) | 50552..51004 | - | 453 | WP_001312282.1 | late promoter-activating protein (Gp10) | - |
H4F95_RS02490 (H4F95_02490) | 51093..52136 | - | 1044 | WP_000648833.1 | DUF968 domain-containing protein | - |
H4F95_RS02495 (H4F95_02495) | 52164..52343 | - | 180 | WP_001448367.1 | hypothetical protein | - |
H4F95_RS02500 (H4F95_02500) | 52348..52728 | - | 381 | WP_089527475.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
H4F95_RS02505 (H4F95_02505) | 52728..52949 | - | 222 | WP_072649184.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
H4F95_RS02510 (H4F95_02510) | 53022..53411 | - | 390 | WP_000506724.1 | S24 family peptidase | - |
H4F95_RS02515 (H4F95_02515) | 53585..54169 | + | 585 | WP_097427909.1 | DNA-binding protein | - |
H4F95_RS02520 (H4F95_02520) | 54170..54532 | + | 363 | WP_044068912.1 | hypothetical protein | - |
H4F95_RS02525 (H4F95_02525) | 54544..54783 | - | 240 | WP_023356286.1 | DNA polymerase III subunit theta | - |
H4F95_RS02530 (H4F95_02530) | 54786..55052 | - | 267 | WP_023356287.1 | hypothetical protein | - |
H4F95_RS02535 (H4F95_02535) | 55098..55358 | - | 261 | WP_128321411.1 | hypothetical protein | - |
H4F95_RS02540 (H4F95_02540) | 55631..56272 | - | 642 | WP_097427911.1 | hypothetical protein | - |
H4F95_RS02545 (H4F95_02545) | 56254..56628 | - | 375 | WP_024236455.1 | hypothetical protein | - |
H4F95_RS02550 (H4F95_02550) | 56635..56928 | - | 294 | WP_000269004.1 | hypothetical protein | - |
H4F95_RS02555 (H4F95_02555) | 57107..57340 | - | 234 | WP_073884956.1 | hypothetical protein | - |
H4F95_RS26300 | 57423..57611 | - | 189 | WP_032352565.1 | DUF551 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaCTX-M-15 | - | 1..101922 | 101922 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13560.28 Da Isoelectric Point: 5.1514
>T202737 WP_089527475.1 NZ_CP075059:c52728-52348 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRKLYGSAE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRKLYGSAE
Download Length: 381 bp
>T202737 NZ_CP099598:c4831597-4831253 [Pseudomonas siliginis]
ATGCGAACAATCTTTTTTGAAACAACGATATTTACCAAAAGCGTTGGTCGCTATCTGACGGACGACGAATATCGAACATT
GCAGAACTACCTTCAGAGCAATCCGCTTGCGGGCGATGTAATGCCTCGAACGGGTGGCTTCCGTAAGCTGCGCTGGGCTG
ACTCTCGCCGTGGCAAGGGAAGACGAGGCGGCTTGCGGGTTCTCTACTATTGTCTTATGAATGATGGTCAGTTCTGGATG
TTCGCCATTTACGACAAAGATGAGCTTGAGAAGCTGACTGCCGAGCAAGAGAGGGCACTCAGGACAGCCATTGATAAAGA
GTTGAAAAAACGAGGTACCCCATGA
ATGCGAACAATCTTTTTTGAAACAACGATATTTACCAAAAGCGTTGGTCGCTATCTGACGGACGACGAATATCGAACATT
GCAGAACTACCTTCAGAGCAATCCGCTTGCGGGCGATGTAATGCCTCGAACGGGTGGCTTCCGTAAGCTGCGCTGGGCTG
ACTCTCGCCGTGGCAAGGGAAGACGAGGCGGCTTGCGGGTTCTCTACTATTGTCTTATGAATGATGGTCAGTTCTGGATG
TTCGCCATTTACGACAAAGATGAGCTTGAGAAGCTGACTGCCGAGCAAGAGAGGGCACTCAGGACAGCCATTGATAAAGA
GTTGAAAAAACGAGGTACCCCATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8105.04 Da Isoelectric Point: 4.7708
>AT202737 WP_072649184.1 NZ_CP075059:c52949-52728 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELANR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELANR
Download Length: 222 bp
>AT202737 NZ_CP099598:c4831256-4830942 [Pseudomonas siliginis]
ATGAAAAAACGCGACCTGTTTGCAGAGTTAATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAGGGCAAGATCACACT
GCGCAATACAGTGCTTGAGGACAAGCCTGTACCTGAAGTGGGCGCACAGGAAATTGTTGCTCTTCGAGAAAAACTGCATA
TGTCTCAAGCTGTTTTTGCCAGTCGAATCAGGACAAGTCCAAACACCCTTCGAAATTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAAGCAGCCTTATTGATACGACTGGTTGAAAAATTTCCAGATATGGTTGAGCGCTTGAACACTGTTTGA
ATGAAAAAACGCGACCTGTTTGCAGAGTTAATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAGGGCAAGATCACACT
GCGCAATACAGTGCTTGAGGACAAGCCTGTACCTGAAGTGGGCGCACAGGAAATTGTTGCTCTTCGAGAAAAACTGCATA
TGTCTCAAGCTGTTTTTGCCAGTCGAATCAGGACAAGTCCAAACACCCTTCGAAATTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAAGCAGCCTTATTGATACGACTGGTTGAAAAATTTCCAGATATGGTTGAGCGCTTGAACACTGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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