Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 52348..52949 Replicon plasmid pCTX_B2_4
Accession NZ_CP075059
Organism Escherichia coli strain TCM_B_2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H4F95_RS02500 Protein ID WP_089527475.1
Coordinates 52348..52728 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H4F95_RS02505 Protein ID WP_072649184.1
Coordinates 52728..52949 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F95_RS26295 47451..47570 - 120 WP_071527722.1 ash family protein -
H4F95_RS02475 (H4F95_02475) 47792..49276 - 1485 WP_155053612.1 terminase -
H4F95_RS02480 (H4F95_02480) 49276..50469 - 1194 WP_000219605.1 terminase -
H4F95_RS02485 (H4F95_02485) 50552..51004 - 453 WP_001312282.1 late promoter-activating protein (Gp10) -
H4F95_RS02490 (H4F95_02490) 51093..52136 - 1044 WP_000648833.1 DUF968 domain-containing protein -
H4F95_RS02495 (H4F95_02495) 52164..52343 - 180 WP_001448367.1 hypothetical protein -
H4F95_RS02500 (H4F95_02500) 52348..52728 - 381 WP_089527475.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H4F95_RS02505 (H4F95_02505) 52728..52949 - 222 WP_072649184.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H4F95_RS02510 (H4F95_02510) 53022..53411 - 390 WP_000506724.1 S24 family peptidase -
H4F95_RS02515 (H4F95_02515) 53585..54169 + 585 WP_097427909.1 DNA-binding protein -
H4F95_RS02520 (H4F95_02520) 54170..54532 + 363 WP_044068912.1 hypothetical protein -
H4F95_RS02525 (H4F95_02525) 54544..54783 - 240 WP_023356286.1 DNA polymerase III subunit theta -
H4F95_RS02530 (H4F95_02530) 54786..55052 - 267 WP_023356287.1 hypothetical protein -
H4F95_RS02535 (H4F95_02535) 55098..55358 - 261 WP_128321411.1 hypothetical protein -
H4F95_RS02540 (H4F95_02540) 55631..56272 - 642 WP_097427911.1 hypothetical protein -
H4F95_RS02545 (H4F95_02545) 56254..56628 - 375 WP_024236455.1 hypothetical protein -
H4F95_RS02550 (H4F95_02550) 56635..56928 - 294 WP_000269004.1 hypothetical protein -
H4F95_RS02555 (H4F95_02555) 57107..57340 - 234 WP_073884956.1 hypothetical protein -
H4F95_RS26300 57423..57611 - 189 WP_032352565.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 - 1..101922 101922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13560.28 Da        Isoelectric Point: 5.1514

>T202737 WP_089527475.1 NZ_CP075059:c52728-52348 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRKLYGSAE

Download         Length: 381 bp

>T202737 NZ_CP099598:c4831597-4831253 [Pseudomonas siliginis]
ATGCGAACAATCTTTTTTGAAACAACGATATTTACCAAAAGCGTTGGTCGCTATCTGACGGACGACGAATATCGAACATT
GCAGAACTACCTTCAGAGCAATCCGCTTGCGGGCGATGTAATGCCTCGAACGGGTGGCTTCCGTAAGCTGCGCTGGGCTG
ACTCTCGCCGTGGCAAGGGAAGACGAGGCGGCTTGCGGGTTCTCTACTATTGTCTTATGAATGATGGTCAGTTCTGGATG
TTCGCCATTTACGACAAAGATGAGCTTGAGAAGCTGACTGCCGAGCAAGAGAGGGCACTCAGGACAGCCATTGATAAAGA
GTTGAAAAAACGAGGTACCCCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8105.04 Da        Isoelectric Point: 4.7708

>AT202737 WP_072649184.1 NZ_CP075059:c52949-52728 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELANR

Download         Length: 222 bp

>AT202737 NZ_CP099598:c4831256-4830942 [Pseudomonas siliginis]
ATGAAAAAACGCGACCTGTTTGCAGAGTTAATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAGGGCAAGATCACACT
GCGCAATACAGTGCTTGAGGACAAGCCTGTACCTGAAGTGGGCGCACAGGAAATTGTTGCTCTTCGAGAAAAACTGCATA
TGTCTCAAGCTGTTTTTGCCAGTCGAATCAGGACAAGTCCAAACACCCTTCGAAATTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAAGCAGCCTTATTGATACGACTGGTTGAAAAATTTCCAGATATGGTTGAGCGCTTGAACACTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References