Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1274597..1275514 | Replicon | chromosome |
| Accession | NZ_CP075055 | ||
| Organism | Bacillus velezensis strain YYC | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | KIV13_RS06725 | Protein ID | WP_032866111.1 |
| Coordinates | 1274768..1275514 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | KIV13_RS06720 | Protein ID | WP_003154807.1 |
| Coordinates | 1274597..1274767 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KIV13_RS06685 (KIV13_06685) | 1269830..1271452 | + | 1623 | WP_032866113.1 | pyocin knob domain-containing protein | - |
| KIV13_RS06690 (KIV13_06690) | 1271465..1271836 | + | 372 | WP_020955692.1 | XkdW family protein | - |
| KIV13_RS06695 (KIV13_06695) | 1271841..1272038 | + | 198 | WP_020955693.1 | XkdX family protein | - |
| KIV13_RS06700 (KIV13_06700) | 1272095..1272856 | + | 762 | WP_020955694.1 | hypothetical protein | - |
| KIV13_RS06705 (KIV13_06705) | 1272908..1273171 | + | 264 | WP_032866112.1 | hemolysin XhlA family protein | - |
| KIV13_RS06710 (KIV13_06710) | 1273185..1273448 | + | 264 | WP_003154813.1 | phage holin | - |
| KIV13_RS06715 (KIV13_06715) | 1273462..1274340 | + | 879 | WP_020955695.1 | N-acetylmuramoyl-L-alanine amidase | - |
| KIV13_RS19560 | 1274375..1274500 | - | 126 | WP_023356844.1 | hypothetical protein | - |
| KIV13_RS06720 (KIV13_06720) | 1274597..1274767 | - | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| KIV13_RS06725 (KIV13_06725) | 1274768..1275514 | - | 747 | WP_032866111.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| KIV13_RS06730 (KIV13_06730) | 1275618..1276616 | - | 999 | WP_020955696.1 | inorganic phosphate transporter | - |
| KIV13_RS06735 (KIV13_06735) | 1276629..1277246 | - | 618 | WP_003154804.1 | DUF47 domain-containing protein | - |
| KIV13_RS06740 (KIV13_06740) | 1277532..1278848 | - | 1317 | WP_007610842.1 | amino acid permease | - |
| KIV13_RS06745 (KIV13_06745) | 1279171..1280121 | + | 951 | WP_012117369.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1241121..1289867 | 48746 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29095.60 Da Isoelectric Point: 4.7755
>T202730 WP_032866111.1 NZ_CP075055:c1275514-1274768 [Bacillus velezensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T202730 NZ_CP099597:c20661-20479 [Pseudomonas siliginis]
ATGAAGTGCAGCGAGTTTCGGCGGTGGTTGTTGGCCCAAGGCGTGGAGTTCAAGAGCGCTAAAGGCAGTCACTTCAAGGT
CTACTTGAATGGCAAGTCAACTATCTTTGCGGATCACGGCAGCAAGGAAATGCACGAAGGATTACGCAAAACCATTATCA
AACAGCTGGGCCTCAAGGATTGA
ATGAAGTGCAGCGAGTTTCGGCGGTGGTTGTTGGCCCAAGGCGTGGAGTTCAAGAGCGCTAAAGGCAGTCACTTCAAGGT
CTACTTGAATGGCAAGTCAACTATCTTTGCGGATCACGGCAGCAAGGAAATGCACGAAGGATTACGCAAAACCATTATCA
AACAGCTGGGCCTCAAGGATTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT202730 WP_003154807.1 NZ_CP075055:c1274767-1274597 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT202730 NZ_CP099597:c20449-20027 [Pseudomonas siliginis]
ATGTATCAATACCCGCTAGAAGTGCATCGTGAACCGACCGGCGTATGGCTGTCATGCCCGGACATTCCGGAAATGAACGC
GGCCGGCGATACCTTGGCAGATGCGTTCGCCGAAGCCTTGAACGGCATGGAATCGGCTTTGTCGCTGTACGTCGAGCAGC
GGCGCAAAATCCCCGCAGCCTCGGCGCCGAGCGATCCGGCCCTGGTGCTGCATTTGCCAGCGCTGACCGTGGCCAAAATT
ATGCTGTGGAATGCCATGCTCGAGGAAGACGTGAGCCGCGCCGAACTGGCCCGGCGCCTGGGCTGTTCGCGCCAGGTGGT
CGATCGCCTGGTCGACTTTATCCATGCTTCCAAGATCGAGCAGGTCGAGCGCGCGTTAGGTCTGTTGGGACGTCGTCTGT
CCCTGGTGCTGGAAGCAGCGTAA
ATGTATCAATACCCGCTAGAAGTGCATCGTGAACCGACCGGCGTATGGCTGTCATGCCCGGACATTCCGGAAATGAACGC
GGCCGGCGATACCTTGGCAGATGCGTTCGCCGAAGCCTTGAACGGCATGGAATCGGCTTTGTCGCTGTACGTCGAGCAGC
GGCGCAAAATCCCCGCAGCCTCGGCGCCGAGCGATCCGGCCCTGGTGCTGCATTTGCCAGCGCTGACCGTGGCCAAAATT
ATGCTGTGGAATGCCATGCTCGAGGAAGACGTGAGCCGCGCCGAACTGGCCCGGCGCCTGGGCTGTTCGCGCCAGGTGGT
CGATCGCCTGGTCGACTTTATCCATGCTTCCAAGATCGAGCAGGTCGAGCGCGCGTTAGGTCTGTTGGGACGTCGTCTGT
CCCTGGTGCTGGAAGCAGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|