Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 484895..485532 | Replicon | chromosome |
| Accession | NZ_CP075055 | ||
| Organism | Bacillus velezensis strain YYC | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | KIV13_RS02460 | Protein ID | WP_003156187.1 |
| Coordinates | 485182..485532 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | KIV13_RS02455 | Protein ID | WP_003156188.1 |
| Coordinates | 484895..485176 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KIV13_RS02435 (KIV13_02435) | 481260..481859 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
| KIV13_RS02440 (KIV13_02440) | 481952..482317 | + | 366 | WP_007410229.1 | holo-ACP synthase | - |
| KIV13_RS02445 (KIV13_02445) | 482482..483489 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| KIV13_RS02450 (KIV13_02450) | 483606..484775 | + | 1170 | WP_032866888.1 | alanine racemase | - |
| KIV13_RS02455 (KIV13_02455) | 484895..485176 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| KIV13_RS02460 (KIV13_02460) | 485182..485532 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| KIV13_RS02465 (KIV13_02465) | 485650..486471 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| KIV13_RS02470 (KIV13_02470) | 486476..486841 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
| KIV13_RS02475 (KIV13_02475) | 486844..487245 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| KIV13_RS02480 (KIV13_02480) | 487257..488264 | + | 1008 | WP_007410233.1 | PP2C family protein-serine/threonine phosphatase | - |
| KIV13_RS02485 (KIV13_02485) | 488328..488657 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| KIV13_RS02490 (KIV13_02490) | 488654..489136 | + | 483 | WP_003156173.1 | anti-sigma B factor RsbW | - |
| KIV13_RS02495 (KIV13_02495) | 489102..489890 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| KIV13_RS02500 (KIV13_02500) | 489890..490492 | + | 603 | WP_007410234.1 | PP2C family serine/threonine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T202729 WP_003156187.1 NZ_CP075055:485182-485532 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T202729 NZ_CP099596:c4858066-4857722 [Pseudomonas siliginis]
ATGCGAACAATCTTTTTTGAAACAACGATATTTACCAAAAGCGTTGGTCGCTATCTGACGGACGACGAATATCGAACATT
GCAGAACTACCTTCAGAGCAATCCGCTTGCGGGCGATGTAATGCCTCGAACGGGTGGCTTCCGTAAGCTGCGCTGGGCTG
ATTCTCGCCGTGGCAAGGGAAGACGAGGCGGCTTGCGGGTTCTCTACTATTGGCTTATGAATGATGGTCAGTTCTGGATG
TTCGCCATTTACGACAAAGATGAGCTTGAGAAGCTGACTGCCGAGCAAGAGAGGGCACTCAGGACAGCCATTGATAAAGA
GTTGAAAAAACGAGGTACCCCATGA
ATGCGAACAATCTTTTTTGAAACAACGATATTTACCAAAAGCGTTGGTCGCTATCTGACGGACGACGAATATCGAACATT
GCAGAACTACCTTCAGAGCAATCCGCTTGCGGGCGATGTAATGCCTCGAACGGGTGGCTTCCGTAAGCTGCGCTGGGCTG
ATTCTCGCCGTGGCAAGGGAAGACGAGGCGGCTTGCGGGTTCTCTACTATTGGCTTATGAATGATGGTCAGTTCTGGATG
TTCGCCATTTACGACAAAGATGAGCTTGAGAAGCTGACTGCCGAGCAAGAGAGGGCACTCAGGACAGCCATTGATAAAGA
GTTGAAAAAACGAGGTACCCCATGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT202729 WP_003156188.1 NZ_CP075055:484895-485176 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT202729 NZ_CP099596:c4857725-4857411 [Pseudomonas siliginis]
ATGAAAAAACGCGACCTGTTTGCAGAGTTAATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAGGGCAAGATCACACT
GCGCAATACAGTGCTTGAGGACAAGCCTGTACCTGAAGTGGGCGCACAGGAAATTGTGGCTCTTCGAGAAAAACTGCATA
TGTCTCAAGCTGTTTTTGCCAGTCGAATCAGGACAAGTCCAAACACCCTTCGAAATTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAAGCAGCCTTATTGATACGACTGGTTGAAAAATTTCCAGATATGGTTGAGCGCTTGAACACTGTTTGA
ATGAAAAAACGCGACCTGTTTGCAGAGTTAATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAGGGCAAGATCACACT
GCGCAATACAGTGCTTGAGGACAAGCCTGTACCTGAAGTGGGCGCACAGGAAATTGTGGCTCTTCGAGAAAAACTGCATA
TGTCTCAAGCTGTTTTTGCCAGTCGAATCAGGACAAGTCCAAACACCCTTCGAAATTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAAGCAGCCTTATTGATACGACTGGTTGAAAAATTTCCAGATATGGTTGAGCGCTTGAACACTGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|