Detailed information of TA system TA202726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3747905..3748541
• Replicon: chromosome
• Accession: NZ_CP075052
• Organism: Bacillus altitudinis strain LZP 02

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K2MHT4
• Locus tag: KIV12_RS19155
• Protein ID: WP_003214169.1
• Coordinates: 3747905..3748255 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: W8QJ31
• Locus tag: KIV12_RS19160
• Protein ID: WP_003214273.1
• Coordinates: 3748260..3748541 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIV12_RS19115 (KIV12_19115)	3742938..3743537	-	600	WP_024719202.1	PP2C family serine/threonine-protein phosphatase	-
KIV12_RS19120 (KIV12_19120)	3743537..3744325	-	789	WP_217967517.1	RNA polymerase sigma factor SigB	-
KIV12_RS19125 (KIV12_19125)	3744291..3744779	-	489	WP_024719203.1	anti-sigma B factor RsbW	-
KIV12_RS19130 (KIV12_19130)	3744776..3745105	-	330	WP_017358393.1	anti-sigma factor antagonist	-
KIV12_RS19135 (KIV12_19135)	3745165..3746172	-	1008	WP_017358394.1	PP2C family protein-serine/threonine phosphatase	-
KIV12_RS19140 (KIV12_19140)	3746183..3746584	-	402	WP_003214085.1	anti-sigma regulatory factor	-
KIV12_RS19145 (KIV12_19145)	3746587..3746955	-	369	WP_003214235.1	RsbT antagonist protein RsbS	-
KIV12_RS19150 (KIV12_19150)	3746960..3747790	-	831	WP_058336383.1	RsbT co-antagonist protein RsbRA	-
KIV12_RS19155 (KIV12_19155)	3747905..3748255	-	351	WP_003214169.1	type II toxin-antitoxin system endoribonuclease NdoA	Toxin
KIV12_RS19160 (KIV12_19160)	3748260..3748541	-	282	WP_003214273.1	hypothetical protein	Antitoxin
KIV12_RS19165 (KIV12_19165)	3748839..3750017	-	1179	WP_217967518.1	alanine racemase	-
KIV12_RS19170 (KIV12_19170)	3750146..3751162	-	1017	WP_007496489.1	outer membrane lipoprotein-sorting protein	-
KIV12_RS19175 (KIV12_19175)	3751323..3751688	-	366	WP_017366663.1	holo-ACP synthase	-
KIV12_RS19180 (KIV12_19180)	3751783..3752388	+	606	WP_007496491.1	rhomboid family intramembrane serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12976.99 Da
• Isoelectric Point: 5.1663

>T202726 WP_003214169.1 NZ_CP075052:c3748255-3747905 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Nucleotide

• Length: 351 bp

>T202726 NZ_CP099596:c906102-905851 [Pseudomonas siliginis]
ATGTCAAAGACTGAAAAACTTCTCGCCAAACTAGTCAACGGCCAAAGCGCATTCACATGGTCCGAGTTTGTCACTCTGTT
GGCGCGTCTTGGTTACTCTCAGCTGGAAGGATCCGGTAGCAGGATCAAATTCGACAACGGGAATCCGAGCGCAATGATCA
ACCTGCACAAGCCACATCCCGGAAATGAAATCAAAACATACGCAAGACGCCAGATTATCGAGCAACTGAAAACAGGAGGC
CTGATTCCATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10864.25 Da
• Isoelectric Point: 5.2726

>AT202726 WP_003214273.1 NZ_CP075052:c3748541-3748260 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Nucleotide

• Length: 282 bp

>AT202726 NZ_CP099596:c905854-905513 [Pseudomonas siliginis]
ATGAGTTCCCAGCTGCACTACAAAGGCTATGTTGGCTCTATCGAGGCGAGCACGGAAGATAAGTGCCTGTTCGGAAAACT
CCTTTTCATCAGGGCGCTGGTTAATTATGAAGGACAAACGGTGGCTGAACTGGAAGCAGCCTTTCGCGAGGCGGTAGATG
ACTATTTACAAACCTGTCAGCAGCTCGGGCAGAAGCCTGAAATCCCATGCAAAGGATCGTTCAATGTTCGCATAGGTCAC
GATCTGCATTTAGCAGCGGCTCTGGCGGCAACCCGTCAAAATGTGTCGTTGAATGATCTGACACGTCAAGCACTGAACGA
ATACCTCCAACACCACGCATAA

Structures

Toxin

• AlphaFold DB: K2MHT4

Antitoxin

• AlphaFold DB: A0A081L854