Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 17559..18184 Replicon plasmid pCFSAN012622
Accession NZ_CP075038
Organism Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)


Gene name vapC Uniprot ID A0A829CIH3
Locus tag GJ28_RS22255 Protein ID WP_001377646.1
Coordinates 17559..17957 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag GJ28_RS22260 Protein ID WP_000450532.1
Coordinates 17957..18184 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ28_RS22235 (13178) 13178..13489 - 312 WP_031570490.1 heavy metal-binding domain-containing protein -
GJ28_RS22240 (13643) 13643..14431 + 789 WP_031615778.1 hypothetical protein -
GJ28_RS22245 (14607) 14607..15341 + 735 WP_031570496.1 hypothetical protein -
GJ28_RS22250 (15397) 15397..17550 + 2154 WP_031570500.1 type IV conjugative transfer system coupling protein TraD -
GJ28_RS22255 (17559) 17559..17957 - 399 WP_001377646.1 type II toxin-antitoxin system VapC family toxin Toxin
GJ28_RS22260 (17957) 17957..18184 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeH / faeI / faeJ / invA / invC/sctN / spaP / spaQ / prgI / papD / papC 1..147099 147099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14912.23 Da        Isoelectric Point: 9.2199

>T202724 WP_001377646.1 NZ_CP075038:c17957-17559 [Salmonella enterica subsp. enterica serovar Give]
MLKFMLDTNICIFTIKNKPARVRDRFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T202724 NZ_CP099591:65943-66092 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT202724 WP_000450532.1 NZ_CP075038:c18184-17957 [Salmonella enterica subsp. enterica serovar Give]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT202724 NZ_CP099591:c65899-65838 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIH3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References