Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3994714..3995230 Replicon chromosome
Accession NZ_CP075037
Organism Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag GJ28_RS19250 Protein ID WP_000220578.1
Coordinates 3994714..3994998 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag GJ28_RS19255 Protein ID WP_000212724.1
Coordinates 3994988..3995230 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ28_RS19235 (3990536) 3990536..3991276 + 741 WP_223202802.1 GIY-YIG nuclease family protein -
GJ28_RS19240 (3991891) 3991891..3994029 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
GJ28_RS19245 (3994246) 3994246..3994710 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GJ28_RS19250 (3994714) 3994714..3994998 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJ28_RS19255 (3994988) 3994988..3995230 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJ28_RS19260 (3995308) 3995308..3997221 - 1914 WP_001212131.1 BglG family transcription antiterminator -
GJ28_RS19265 (3997238) 3997238..3997978 - 741 WP_000779263.1 KDGP aldolase family protein -
GJ28_RS19270 (3997975) 3997975..3999093 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GJ28_RS19275 (3999077) 3999077..4000210 - 1134 WP_000459945.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T202720 WP_000220578.1 NZ_CP075037:c3994998-3994714 [Salmonella enterica subsp. enterica serovar Give]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202720 NZ_CP099590:c4103751-4103401 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202720 WP_000212724.1 NZ_CP075037:c3995230-3994988 [Salmonella enterica subsp. enterica serovar Give]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202720 NZ_CP099590:c4103996-4103745 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References