Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3314143..3314763 Replicon chromosome
Accession NZ_CP075037
Organism Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag GJ28_RS16180 Protein ID WP_001280991.1
Coordinates 3314545..3314763 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag GJ28_RS16175 Protein ID WP_000344807.1
Coordinates 3314143..3314517 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ28_RS16165 (3309282) 3309282..3310475 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJ28_RS16170 (3310498) 3310498..3313647 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
GJ28_RS16175 (3314143) 3314143..3314517 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
GJ28_RS16180 (3314545) 3314545..3314763 + 219 WP_001280991.1 HHA domain-containing protein Toxin
GJ28_RS16185 (3314942) 3314942..3315493 + 552 WP_001278791.1 maltose O-acetyltransferase -
GJ28_RS16190 (3315611) 3315611..3316081 + 471 WP_000136183.1 YlaC family protein -
GJ28_RS16195 (3316137) 3316137..3316277 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
GJ28_RS16200 (3316279) 3316279..3316542 - 264 WP_000801416.1 type B 50S ribosomal protein L31 -
GJ28_RS16205 (3316767) 3316767..3318317 + 1551 WP_023260098.1 EAL domain-containing protein -
GJ28_RS16215 (3318548) 3318548..3318937 + 390 WP_000961285.1 MGMT family protein -
GJ28_RS16220 (3318970) 3318970..3319539 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202718 WP_001280991.1 NZ_CP075037:3314545-3314763 [Salmonella enterica subsp. enterica serovar Give]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202718 NZ_CP099590:3973164-3973505 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202718 WP_000344807.1 NZ_CP075037:3314143-3314517 [Salmonella enterica subsp. enterica serovar Give]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202718 NZ_CP099590:c3973169-3973093 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References