Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822352..823012 Replicon chromosome
Accession NZ_CP075037
Organism Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag GJ28_RS03955 Protein ID WP_000244757.1
Coordinates 822599..823012 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag GJ28_RS03950 Protein ID WP_000351186.1
Coordinates 822352..822618 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ28_RS03930 (818280) 818280..819713 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
GJ28_RS03935 (819872) 819872..820183 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
GJ28_RS03940 (820347) 820347..821006 + 660 WP_000250289.1 hemolysin III family protein -
GJ28_RS03945 (821122) 821122..822102 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
GJ28_RS03950 (822352) 822352..822618 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
GJ28_RS03955 (822599) 822599..823012 + 414 WP_000244757.1 protein YgfX Toxin
GJ28_RS03960 (823065) 823065..823586 - 522 WP_001055885.1 flavodoxin FldB -
GJ28_RS03965 (823699) 823699..824595 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
GJ28_RS03970 (824619) 824619..825332 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJ28_RS03975 (825338) 825338..827071 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T202707 WP_000244757.1 NZ_CP075037:822599-823012 [Salmonella enterica subsp. enterica serovar Give]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T202707 NZ_CP099590:1781593-1781847 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202707 WP_000351186.1 NZ_CP075037:822352-822618 [Salmonella enterica subsp. enterica serovar Give]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202707 NZ_CP099590:1781345-1781596 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References