Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200610..201370 Replicon chromosome
Accession NZ_CP075037
Organism Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag GJ28_RS00935 Protein ID WP_000533909.1
Coordinates 200885..201370 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag GJ28_RS00930 Protein ID WP_000965889.1
Coordinates 200610..200897 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ28_RS00915 (196108) 196108..198177 + 2070 WP_001291743.1 glycine--tRNA ligase subunit beta -
GJ28_RS23020 (198566) 198566..198994 + 429 Protein_182 IS3 family transposase -
GJ28_RS00925 (199359) 199359..200264 + 906 WP_031567314.1 hypothetical protein -
GJ28_RS00930 (200610) 200610..200897 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
GJ28_RS00935 (200885) 200885..201370 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
GJ28_RS00940 (201742) 201742..202281 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
GJ28_RS00945 (202453) 202453..202665 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
GJ28_RS00950 (202953) 202953..203243 - 291 WP_000455790.1 HTH-type transcriptional regulator -
GJ28_RS00955 (203682) 203682..204392 + 711 WP_000190524.1 DUF3053 domain-containing protein -
GJ28_RS00960 (204442) 204442..205416 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
GJ28_RS00965 (205646) 205646..206308 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202706 WP_000533909.1 NZ_CP075037:200885-201370 [Salmonella enterica subsp. enterica serovar Give]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202706 NZ_CP099590:1781345-1781596 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT202706 WP_000965889.1 NZ_CP075037:200610-200897 [Salmonella enterica subsp. enterica serovar Give]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202706 NZ_CP099590:1781593-1781847 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References