Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2177665..2179301 Replicon chromosome
Accession NZ_CP074710
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hipA Uniprot ID A0A1E3M7C1
Locus tag KIP77_RS11440 Protein ID WP_000737056.1
Coordinates 2177665..2178996 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KIP77_RS11445 Protein ID WP_001101308.1
Coordinates 2178993..2179301 (+) Length 103 a.a.

Genomic Context

KIP77_RS11420KIP77_RS11425KIP77_RS11430KIP77_RS11440KIP77_RS11445KIP77_RS11450KIP77_RS11455KIP77_RS11460KIP77_RS11465KIP77_RS11470KIP77_RS11475KIP77_RS11435
Location: 2173980..2175140 (1161 bp)
Type: Others
Protein ID: WP_001044492.1
Location: 2175267..2176238 (972 bp)
Type: Others
Protein ID: WP_109104914.1
Location: 2176250..2176894 (645 bp)
Type: Others
Protein ID: WP_000817301.1
Location: 2177665..2178996 (1332 bp)
Type: Toxin
Protein ID: WP_000737056.1
Location: 2178993..2179301 (309 bp)
Type: Antitoxin
Protein ID: WP_001101308.1
Location: 2180027..2180578 (552 bp)
Type: Others
Protein ID: WP_049594830.1
Location: 2180794..2181414 (621 bp)
Type: Others
Protein ID: WP_000658761.1
Location: 2181432..2182514 (1083 bp)
Type: Others
Protein ID: WP_001095788.1
Location: 2182556..2183071 (516 bp)
Type: Others
Protein ID: WP_000914805.1
Location: 2183219..2183737 (519 bp)
Type: Others
Protein ID: WP_000651611.1
Location: 2183718..2183849 (132 bp)
Type: Others
Protein ID: Protein_2027
Location: 2176929..2177369 (441 bp)
Type: Others
Protein ID: WP_000193135.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KIP77_RS11420 (KIP77_11380)2173980..2175140+1161WP_001044492.1hypothetical protein-
KIP77_RS11425 (KIP77_11385)2175267..2176238+972WP_109104914.15'/3'-nucleotidase SurE-
KIP77_RS11430 (KIP77_11390)2176250..2176894+645WP_000817301.1hypothetical protein-
KIP77_RS11435 (KIP77_11395)2176929..2177369-441WP_000193135.1HD domain-containing protein-
KIP77_RS11440 (KIP77_11400)2177665..2178996+1332WP_000737056.1HipA domain-containing proteinToxin
KIP77_RS11445 (KIP77_11405)2178993..2179301+309WP_001101308.1helix-turn-helix domain-containing proteinAntitoxin
KIP77_RS11450 (KIP77_11410)2180027..2180578+552WP_049594830.1TetR/AcrR family transcriptional regulator-
KIP77_RS11455 (KIP77_11415)2180794..2181414+621WP_000658761.1hypothetical protein-
KIP77_RS11460 (KIP77_11420)2181432..2182514+1083WP_001095788.1XRE family transcriptional regulator-
KIP77_RS11465 (KIP77_11425)2182556..2183071+516WP_000914805.1hypothetical protein-
KIP77_RS11470 (KIP77_11430)2183219..2183737+519WP_000651611.1GNAT family N-acetyltransferase-
KIP77_RS114752183718..2183849+132Protein_2027TetR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.16 Da        Isoelectric Point: 4.7456

>T202699 WP_000737056.1 NZ_CP074710:2177665-2178996 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T202699 NZ_CP099590:c605637-605173 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT202699 WP_001101308.1 NZ_CP074710:2178993-2179301 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT202699 NZ_CP099590:c605972-605637 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E3M7C1

Antitoxin

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Source
ID
Structure
No matching records found

References