Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 720689..721342 Replicon chromosome
Accession NZ_CP074710
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag KIP77_RS04555 Protein ID WP_009518132.1
Coordinates 720953..721342 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KIP77_RS04550 Protein ID WP_001288210.1
Coordinates 720689..720946 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP77_RS04530 (KIP77_04525) 716204..717211 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KIP77_RS04535 (KIP77_04530) 717230..717607 + 378 WP_001216380.1 50S ribosomal protein L17 -
KIP77_RS04540 (KIP77_04535) 717789..719279 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
KIP77_RS04545 (KIP77_04540) 719329..720501 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
KIP77_RS04550 (KIP77_04545) 720689..720946 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KIP77_RS04555 (KIP77_04550) 720953..721342 + 390 WP_009518132.1 hypothetical protein Toxin
KIP77_RS04560 (KIP77_04555) 722112..723197 + 1086 WP_000049106.1 hypothetical protein -
KIP77_RS04565 (KIP77_04560) 723276..723842 + 567 WP_000651535.1 rhombosortase -
KIP77_RS04570 (KIP77_04565) 724030..726225 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T202697 WP_009518132.1 NZ_CP074710:720953-721342 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T202697 NZ_CP099589:c90219-89914 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT202697 WP_001288210.1 NZ_CP074710:720689-720946 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT202697 NZ_CP099589:c90439-90221 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References