Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 8862..9390 Replicon plasmid unnamed3
Accession NZ_CP074707
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag KIP77_RS00065 Protein ID WP_000221358.1
Coordinates 9097..9390 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag KIP77_RS00060 Protein ID WP_000246756.1
Coordinates 8862..9107 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP77_RS00025 (KIP77_00025) 3951..4649 + 699 WP_000007662.1 CPBP family glutamic-type intramembrane protease -
KIP77_RS00030 (KIP77_00030) 4771..4968 - 198 WP_001282483.1 hypothetical protein -
KIP77_RS00035 (KIP77_00035) 4968..5339 - 372 WP_000504218.1 hypothetical protein -
KIP77_RS00040 (KIP77_00040) 6549..7499 + 951 WP_001205343.1 replication initiation protein RepM -
KIP77_RS00045 (KIP77_00045) 7492..8067 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
KIP77_RS00050 (KIP77_00050) 8087..8230 + 144 WP_001125244.1 hypothetical protein -
KIP77_RS00055 (KIP77_00055) 8415..8618 - 204 WP_000482656.1 hypothetical protein -
KIP77_RS00060 (KIP77_00060) 8862..9107 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KIP77_RS00065 (KIP77_00065) 9097..9390 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIP77_RS00070 (KIP77_00070) 9608..10810 + 1203 WP_061855756.1 alpha/beta fold hydrolase -
KIP77_RS00075 (KIP77_00075) 10908..11681 + 774 WP_061855758.1 glucose 1-dehydrogenase -
KIP77_RS00080 (KIP77_00080) 12028..12315 + 288 WP_000438826.1 BrnT family toxin -
KIP77_RS00085 (KIP77_00085) 12302..12616 + 315 WP_061855757.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..20351 20351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T202695 WP_000221358.1 NZ_CP074707:9097-9390 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T202695 NZ_CP099589:c34695-34546 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT202695 WP_000246756.1 NZ_CP074707:8862-9107 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT202695 NZ_CP099589:34739-34800 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References