Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4918990..4919695 Replicon chromosome
Accession NZ_CP074701
Organism Escherichia coli strain 702/18

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag KH969_RS23590 Protein ID WP_000539521.1
Coordinates 4919309..4919695 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KH969_RS23585 Protein ID WP_001280945.1
Coordinates 4918990..4919319 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH969_RS23570 (4914148) 4914148..4915059 + 912 WP_001236058.1 glutathione ABC transporter permease GsiD -
KH969_RS23575 (4915236) 4915236..4917584 + 2349 WP_000950337.1 EAL domain-containing protein -
KH969_RS23580 (4917592) 4917592..4918920 + 1329 WP_000086869.1 GGDEF domain-containing protein -
KH969_RS23585 (4918990) 4918990..4919319 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
KH969_RS23590 (4919309) 4919309..4919695 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KH969_RS23595 (4919921) 4919921..4921246 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
KH969_RS23600 (4921459) 4921459..4921842 + 384 WP_000497137.1 biofilm formation regulator BssR -
KH969_RS23605 (4921953) 4921953..4923068 + 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
KH969_RS23610 (4923065) 4923065..4923691 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T202684 WP_000539521.1 NZ_CP074701:c4919695-4919309 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T202684 NZ_CP099588:2598711-2598818 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT202684 WP_001280945.1 NZ_CP074701:c4919319-4918990 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT202684 NZ_CP099588:c2598664-2598598 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References