Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2311809..2312607 Replicon chromosome
Accession NZ_CP074701
Organism Escherichia coli strain 702/18

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag KH969_RS11230 Protein ID WP_000854735.1
Coordinates 2312230..2312607 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag KH969_RS11225 Protein ID WP_001285415.1
Coordinates 2311809..2312183 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH969_RS11190 (2307740) 2307740..2308420 + 681 WP_001282919.1 WYL domain-containing protein -
KH969_RS11195 (2308568) 2308568..2309245 + 678 WP_001097302.1 hypothetical protein -
KH969_RS11200 (2309251) 2309251..2309484 + 234 WP_001278287.1 DUF905 family protein -
KH969_RS11205 (2309574) 2309574..2310392 + 819 WP_001175148.1 DUF932 domain-containing protein -
KH969_RS11210 (2310474) 2310474..2310953 + 480 WP_000844100.1 antirestriction protein -
KH969_RS11215 (2310969) 2310969..2311445 + 477 WP_001366855.1 RadC family protein -
KH969_RS11220 (2311508) 2311508..2311729 + 222 WP_000692309.1 DUF987 domain-containing protein -
KH969_RS11225 (2311809) 2311809..2312183 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KH969_RS11230 (2312230) 2312230..2312607 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
KH969_RS11235 (2312604) 2312604..2313092 + 489 WP_000761676.1 DUF5983 family protein -
KH969_RS11240 (2313104) 2313104..2313301 + 198 WP_000839291.1 DUF957 domain-containing protein -
KH969_RS11245 (2313386) 2313386..2314252 + 867 WP_001280433.1 DUF4942 domain-containing protein -
KH969_RS11250 (2314324) 2314324..2314587 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
KH969_RS11255 (2314584) 2314584..2314910 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
KH969_RS11260 (2315385) 2315385..2315555 + 171 Protein_2221 IS110 family transposase -
KH969_RS11265 (2316366) 2316366..2317349 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T202677 WP_000854735.1 NZ_CP074701:2312230-2312607 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T202677 NZ_CP099588:1779982-1780233 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT202677 WP_001285415.1 NZ_CP074701:2311809-2312183 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT202677 NZ_CP099588:1780230-1780484 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References