Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3481132..3481785 Replicon chromosome
Accession NZ_CP074698
Organism Acinetobacter baumannii strain X4-136

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag IS509_RS16765 Protein ID WP_000607077.1
Coordinates 3481132..3481521 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag IS509_RS16770 Protein ID WP_001288210.1
Coordinates 3481528..3481785 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS509_RS16750 3476250..3478445 - 2196 WP_001158906.1 TRAP transporter large permease subunit -
IS509_RS16755 3478633..3479199 - 567 WP_000651538.1 rhombosortase -
IS509_RS16760 3479277..3480362 - 1086 WP_000049106.1 hypothetical protein -
IS509_RS16765 3481132..3481521 - 390 WP_000607077.1 membrane protein Toxin
IS509_RS16770 3481528..3481785 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
IS509_RS16775 3481973..3483145 + 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
IS509_RS16780 3483194..3484684 - 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
IS509_RS16785 3484866..3485243 - 378 WP_001216380.1 50S ribosomal protein L17 -
IS509_RS16790 3485262..3486269 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T202663 WP_000607077.1 NZ_CP074698:c3481521-3481132 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T202663 NZ_CP099576:c2560799-2560692 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT202663 WP_001288210.1 NZ_CP074698:c3481785-3481528 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT202663 NZ_CP099576:2560615-2560675 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References