202662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2734944..2735595 Replicon chromosome
Accession NZ_CP074698
Organism Acinetobacter baumannii strain X4-136

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag IS509_RS13290 Protein ID WP_000838147.1
Coordinates 2735413..2735595 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag IS509_RS13285 Protein ID WP_002053018.1
Coordinates 2734944..2735348 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS509_RS13270 2730079..2730222 - 144 WP_164523119.1 hypothetical protein -
IS509_RS13275 2730262..2734233 - 3972 WP_279446913.1 tape measure protein -
IS509_RS13280 2734330..2734848 - 519 WP_005070358.1 DUF4468 domain-containing protein -
IS509_RS13285 2734944..2735348 - 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IS509_RS13290 2735413..2735595 - 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
IS509_RS13295 2735927..2736460 - 534 WP_057691629.1 hypothetical protein -
IS509_RS13300 2736505..2737434 - 930 WP_049594449.1 phage tail tube protein -
IS509_RS13305 2737542..2737754 - 213 WP_030423712.1 hypothetical protein -
IS509_RS13310 2737756..2738154 - 399 WP_030423713.1 phage tail terminator-like protein -
IS509_RS13315 2738156..2738524 - 369 WP_001983390.1 hypothetical protein -
IS509_RS13320 2738490..2738903 - 414 WP_031965420.1 hypothetical protein -
IS509_RS13325 2738967..2739419 - 453 WP_002053117.1 hypothetical protein -
IS509_RS13330 2739419..2739838 - 420 WP_002053092.1 hypothetical protein -
IS509_RS13335 2739894..2740262 - 369 WP_025467978.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2718063..2766050 47987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T202662 WP_000838147.1 NZ_CP074698:c2735595-2735413 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T202662 NZ_CP099576:c2535563-2535297 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT202662 WP_002053018.1 NZ_CP074698:c2735348-2734944 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT202662 NZ_CP099576:c2535814-2535563 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References