Detailed information of TA system TA202660

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3935010..3935663
• Replicon: chromosome
• Accession: NZ_CP074695
• Organism: Acinetobacter baumannii strain X4-107

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IS508_RS18990
• Protein ID: WP_000607077.1
• Coordinates: 3935274..3935663 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: IS508_RS18985
• Protein ID: WP_001288210.1
• Coordinates: 3935010..3935267 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS508_RS18965	3930526..3931533	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
IS508_RS18970	3931552..3931929	+	378	WP_001216380.1	50S ribosomal protein L17	-
IS508_RS18975	3932111..3933601	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
IS508_RS18980	3933650..3934822	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
IS508_RS18985	3935010..3935267	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
IS508_RS18990	3935274..3935663	+	390	WP_000607077.1	membrane protein	Toxin
IS508_RS18995	3936433..3937518	+	1086	WP_000049106.1	hypothetical protein	-
IS508_RS19000	3937596..3938162	+	567	WP_000651538.1	rhombosortase	-
IS508_RS19005	3938350..3940545	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T202660 WP_000607077.1 NZ_CP074695:3935274-3935663 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T202660 NZ_CP099576:c2213442-2213233 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT202660 WP_001288210.1 NZ_CP074695:3935010-3935267 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT202660 NZ_CP099576:c2213747-2213454 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7