202659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 709153..709804 Replicon chromosome
Accession NZ_CP074695
Organism Acinetobacter baumannii strain X4-107

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag IS508_RS03290 Protein ID WP_000838147.1
Coordinates 709153..709335 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag IS508_RS03295 Protein ID WP_002053018.1
Coordinates 709400..709804 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS508_RS03245 704486..704854 + 369 WP_025467978.1 hypothetical protein -
IS508_RS03250 704910..705329 + 420 WP_002053092.1 hypothetical protein -
IS508_RS03255 705329..705781 + 453 WP_002053117.1 hypothetical protein -
IS508_RS03260 705845..706258 + 414 WP_031965420.1 hypothetical protein -
IS508_RS03265 706224..706592 + 369 WP_001983390.1 hypothetical protein -
IS508_RS03270 706594..706992 + 399 WP_030423713.1 phage tail terminator-like protein -
IS508_RS03275 706994..707206 + 213 WP_030423712.1 hypothetical protein -
IS508_RS03280 707314..708243 + 930 WP_049594449.1 phage tail tube protein -
IS508_RS03285 708288..708821 + 534 WP_057691629.1 hypothetical protein -
IS508_RS03290 709153..709335 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
IS508_RS03295 709400..709804 + 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IS508_RS03300 709900..710418 + 519 WP_005070358.1 DUF4468 domain-containing protein -
IS508_RS03305 710515..714486 + 3972 WP_279446913.1 tape measure protein -
IS508_RS03310 714526..714669 + 144 WP_164523119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 680713..726685 45972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T202659 WP_000838147.1 NZ_CP074695:709153-709335 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T202659 NZ_CP099576:c2193839-2193477 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT202659 WP_002053018.1 NZ_CP074695:709400-709804 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT202659 NZ_CP099576:c2194006-2193836 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References