Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2612515..2613143 Replicon chromosome
Accession NZ_CP074693
Organism Geobacter sulfurreducens strain YM35

Toxin (Protein)


Gene name vapC Uniprot ID Q74AB8
Locus tag KIP69_RS11965 Protein ID WP_010943110.1
Coordinates 2612515..2612916 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q74AB7
Locus tag KIP69_RS11970 Protein ID WP_010943111.1
Coordinates 2612916..2613143 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP69_RS11945 (KIP69_11945) 2607769..2608524 + 756 WP_014551836.1 GPMC system MBL fold metallohydrolase -
KIP69_RS11950 (KIP69_11950) 2608628..2610472 + 1845 WP_014551837.1 TIGR04442 family protein -
KIP69_RS11955 (KIP69_11955) 2610488..2611861 - 1374 WP_010943105.1 integron integrase -
KIP69_RS11960 (KIP69_11960) 2611942..2612292 + 351 WP_010943106.1 hypothetical protein -
KIP69_RS11965 (KIP69_11965) 2612515..2612916 - 402 WP_010943110.1 type II toxin-antitoxin system VapC family toxin Toxin
KIP69_RS11970 (KIP69_11970) 2612916..2613143 - 228 WP_010943111.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KIP69_RS11975 (KIP69_11975) 2613727..2616537 + 2811 WP_214302592.1 GPMC system transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14702.12 Da        Isoelectric Point: 4.8615

>T202658 WP_010943110.1 NZ_CP074693:c2612916-2612515 [Geobacter sulfurreducens]
MKLLLDTNICIYIIKQQPVAVLERFLEYQVGDIGISSITLSELRYGVAKSTHMEKNAKALDEFIIPLELVSYDESAAHVY
GDIRAALEKAGTPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSLNIIDWTV

Download         Length: 402 bp

>T202658 NZ_CP099576:c2096221-2096045 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8772.02 Da        Isoelectric Point: 10.5623

>AT202658 WP_010943111.1 NZ_CP074693:c2613143-2612916 [Geobacter sulfurreducens]
MKTAKIFQNGQSQAVRLPKEFRFEDSEVFIKKSGNVVQLIPRSDSWNSLFGSLKKFSRDFMSERIQPELDKRDGF

Download         Length: 228 bp

>AT202658 NZ_CP099576:2095922-2095977 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q74AB8

Antitoxin

Source ID Structure
AlphaFold DB Q74AB7

References