Detailed information of TA system TA202657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2579922..2580447
• Replicon: chromosome
• Accession: NZ_CP074693
• Organism: Geobacter sulfurreducens strain YM35

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q74AD7
• Locus tag: KIP69_RS11815
• Protein ID: WP_010943076.1
• Coordinates: 2580157..2580447 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q74AD8
• Locus tag: KIP69_RS11810
• Protein ID: WP_010943075.1
• Coordinates: 2579922..2580167 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIP69_RS11790 (KIP69_11790)	2576024..2576731	-	708	WP_010943071.1	lipoyl(octanoyl) transferase LipB	-
KIP69_RS11795 (KIP69_11795)	2576760..2578016	-	1257	WP_014551815.1	dihydrolipoamide acetyltransferase family protein	-
KIP69_RS11800 (KIP69_11800)	2578032..2579018	-	987	WP_010943073.1	alpha-ketoacid dehydrogenase subunit beta	-
KIP69_RS11805 (KIP69_11805)	2579059..2579544	-	486	WP_214302579.1	VOC family protein	-
KIP69_RS11810 (KIP69_11810)	2579922..2580167	+	246	WP_010943075.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KIP69_RS11815 (KIP69_11815)	2580157..2580447	+	291	WP_010943076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KIP69_RS11820 (KIP69_11820)	2580496..2580912	-	417	WP_014551817.1	hypothetical protein	-
KIP69_RS11825 (KIP69_11825)	2581040..2581786	-	747	WP_045667385.1	class I SAM-dependent methyltransferase	-
KIP69_RS11830 (KIP69_11830)	2582011..2582358	-	348	WP_214302581.1	hypothetical protein	-
KIP69_RS11835 (KIP69_11835)	2582339..2582614	-	276	WP_039643539.1	hypothetical protein	-
KIP69_RS11840 (KIP69_11840)	2582862..2583839	-	978	WP_214302583.1	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-67)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11331.30 Da
• Isoelectric Point: 10.4995

>T202657 WP_010943076.1 NZ_CP074693:2580157-2580447 [Geobacter sulfurreducens]
MSYSLEFKESALKEWKKLDGRIREQFKKKLTERLELPRVEPARLSGMPDCYKIKLKNAGYRLVYQVDDNRIIVTVVAVGK
RENLTVYRAAEKRVKQ

Nucleotide

• Length: 291 bp

>T202657 NZ_CP099576:c1992933-1992781 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9193.46 Da
• Isoelectric Point: 4.6631

>AT202657 WP_010943075.1 NZ_CP074693:2579922-2580167 [Geobacter sulfurreducens]
MERLFARASVSISDLKKNPTRIINQSEGEPVAILNHNKPSAYLIPADAFEALMEKLEDYELSQIVKEREHEPSVKVSLDE
L

Nucleotide

• Length: 246 bp

>AT202657 NZ_CP099576:c1993557-1992958 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: Q74AD7

Antitoxin

• AlphaFold DB: Q74AD8