Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1682047..1682629 Replicon chromosome
Accession NZ_CP074693
Organism Geobacter sulfurreducens strain YM35

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KIP69_RS07730 Protein ID WP_250546393.1
Coordinates 1682405..1682629 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID Q74CX9
Locus tag KIP69_RS07725 Protein ID WP_010942189.1
Coordinates 1682047..1682340 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP69_RS07710 (KIP69_07710) 1678321..1679136 + 816 WP_214303076.1 exodeoxyribonuclease III -
KIP69_RS07715 (KIP69_07715) 1679699..1680502 + 804 WP_214303077.1 transposase -
KIP69_RS07720 (KIP69_07720) 1680555..1681925 + 1371 WP_214303078.1 kelch repeat-containing protein -
KIP69_RS07725 (KIP69_07725) 1682047..1682340 - 294 WP_010942189.1 putative addiction module antidote protein Antitoxin
KIP69_RS07730 (KIP69_07730) 1682405..1682629 - 225 WP_250546393.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIP69_RS07735 (KIP69_07735) 1682743..1683189 + 447 WP_214303079.1 DUF2845 domain-containing protein -
KIP69_RS07740 (KIP69_07740) 1683284..1683898 + 615 WP_010942192.1 LysE family translocator -
KIP69_RS07745 (KIP69_07745) 1684098..1684943 + 846 WP_250546394.1 hypothetical protein -
KIP69_RS07750 (KIP69_07750) 1685023..1686444 + 1422 WP_214303081.1 tetratricopeptide repeat protein -
KIP69_RS07755 (KIP69_07755) 1686545..1687030 + 486 WP_010942195.1 ferritin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-69)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8601.95 Da        Isoelectric Point: 10.7502

>T202656 WP_250546393.1 NZ_CP074693:c1682629-1682405 [Geobacter sulfurreducens]
MIEIRKTELFAKWLDNLRDVKAKARVLVRIERLASGNPGDVKPVGDGISEMRIDYGPGYRVYFFQRGSEFGRRR

Download         Length: 225 bp

>T202656 NZ_CP099576:1934933-1935028 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10451.92 Da        Isoelectric Point: 6.4708

>AT202656 WP_010942189.1 NZ_CP074693:c1682340-1682047 [Geobacter sulfurreducens]
MTKTATSRYDVAEHLRTPEEMAAYLEASLEEANGDATFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERVPSFDT
ILKIIAALGLKLHAEAR

Download         Length: 294 bp

>AT202656 NZ_CP099576:c1935115-1935056 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q74CX9

References