Detailed information of TA system TA202633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2374803..2376391
• Replicon: chromosome
• Accession: NZ_CP074680
• Organism: Escherichia coli strain MEI008

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9XU38
• Locus tag: KIM92_RS11545
• Protein ID: WP_001125455.1
• Coordinates: 2375069..2376391 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KIM92_RS11540
• Protein ID: WP_001296726.1
• Coordinates: 2374803..2375069 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIM92_RS11540 (2374803)	2374803..2375069	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KIM92_RS11545 (2375069)	2375069..2376391	+	1323	WP_001125455.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KIM92_RS11550 (2376703)	2376703..2376911	+	209	Protein_2257	AraC family transcriptional regulator	-
KIM92_RS11555 (2377345)	2377345..2377908	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
KIM92_RS11560 (2378269)	2378269..2378979	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2374803..2390892	16089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49321.93 Da
• Isoelectric Point: 8.8753

>T202633 WP_001125455.1 NZ_CP074680:2375069-2376391 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T202633 NZ_CP099535:1364647-1364744 [Pantoea ananatis]
GCAAGGCGAAAGCCTCTATCAATGCCAACTTTTAGCGCACGGCTCCTTGAGAGCCATTTCCCTGGACCGAATACAGGAAT
CGTGTTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT202633 WP_001296726.1 NZ_CP074680:2374803-2375069 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT202633 NZ_CP099535:c1364744-1364612 [Pantoea ananatis]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTCAAGGAGCCGTGCGCTAAAAGTTGGCATTGA
TAGAGGCTTTCGCCTTGCTTTTAAAGCGTAGGACAACGCGCCAGATTTTCCAG

Structures

Toxin

• AlphaFold DB: U9XU38