Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1333923..1334548 Replicon chromosome
Accession NZ_CP074680
Organism Escherichia coli strain MEI008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KIM92_RS06490 Protein ID WP_000911330.1
Coordinates 1334150..1334548 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KIM92_RS06485 Protein ID WP_000450524.1
Coordinates 1333923..1334150 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM92_RS06460 (1329726) 1329726..1330196 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KIM92_RS06465 (1330196) 1330196..1330768 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KIM92_RS06470 (1330914) 1330914..1331792 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KIM92_RS06475 (1331809) 1331809..1332843 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KIM92_RS06480 (1333056) 1333056..1333769 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KIM92_RS06485 (1333923) 1333923..1334150 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KIM92_RS06490 (1334150) 1334150..1334548 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KIM92_RS06495 (1334695) 1334695..1335558 + 864 WP_001267508.1 neutral zinc metallopeptidase -
KIM92_RS06500 (1335573) 1335573..1337588 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
KIM92_RS06505 (1337662) 1337662..1338360 + 699 WP_000679823.1 esterase -
KIM92_RS06510 (1338470) 1338470..1338670 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T202623 WP_000911330.1 NZ_CP074680:1334150-1334548 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T202623 NZ_CP099531:c4625157-4625005 [Xanthomonas sacchari]
ATGAAGCGACTGACCACCCTGTTGATGCTGACCCTGTTTTGCGCTGGTGTGCTGACCGGCTGCAACACCGTTGCCGGCGC
CGGCAAGGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACACCGCCAAGGATTGCAGCGCGGGCAAGTGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT202623 WP_000450524.1 NZ_CP074680:1333923-1334150 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT202623 NZ_CP099531:c4624949-4624815 [Xanthomonas sacchari]
ATGAAGCGTACGTTTGCGTGGATGCTGCTGGCGATGTTCTCTGTGGGCCTGCTGGCCGGTTGCAACACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCGGGCGAGAAGGTCCAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References