Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 265339..265925 Replicon chromosome
Accession NZ_CP074680
Organism Escherichia coli strain MEI008

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KIM92_RS01180 Protein ID WP_042014162.1
Coordinates 265339..265569 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KIM92_RS01185 Protein ID WP_000593555.1
Coordinates 265566..265925 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM92_RS01170 (261376) 261376..264111 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
KIM92_RS01175 (264111) 264111..265235 + 1125 WP_001314210.1 ABC transporter permease -
KIM92_RS01180 (265339) 265339..265569 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KIM92_RS01185 (265566) 265566..265925 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KIM92_RS01190 (266045) 266045..266446 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KIM92_RS01195 (266452) 266452..267258 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KIM92_RS01200 (267255) 267255..268019 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KIM92_RS01205 (268019) 268019..268852 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
KIM92_RS01210 (268849) 268849..269793 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T202619 WP_042014162.1 NZ_CP074680:265339-265569 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T202619 NZ_CP099531:3790282-3790533 [Xanthomonas sacchari]
ATGGACACCATCACCTACAGCGCCGCACGTGCCGCTCTCGCGGACACCATGGACCGCGTGGTCAACAACCACGAGCCGGT
GATCATTACGCGCAGCCGCGAGCAAGCCGTCGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAAGAAACCGCTTATT
TGCTGCGTAGCCCGAAGAACGCGCAGCGCCTGCTGGAATCCATCGCACAACTCGAATCCGGTCGCGGCAAGGCGCGGGAA
CTGAGCGAGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT202619 WP_000593555.1 NZ_CP074680:265566-265925 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT202619 NZ_CP099531:3790530-3790787 [Xanthomonas sacchari]
GTGACGCTGCAGTTCTCGGACAACGCCTGGGAGGATTATCTCTACTGGCAACAGGCCGACAAAAAGATGCTCAAGCGCAT
CAACGACCTGATCAAGGCCATTCAACGCGATCCCTTGCAGGGCATCGGCAAACCCGAACCGCTACGCCATGCCCTGGCCG
GCTATTGGTCGCGACGCGTCAACGACGAACACCGGATCGTCTATAAGGTCGAGCATGGCGTCCTGTTGATTGCACAACTG
CGGTATCACTACGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References