Detailed information of TA system TA202613

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4712044..4713725
• Replicon: chromosome
• Accession: NZ_CP074677
• Organism: Klebsiella pneumoniae strain MEI009

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KIM99_RS22980
• Protein ID: WP_009309420.1
• Coordinates: 4712044..4712961 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KIM99_RS22985
• Protein ID: WP_004177809.1
• Coordinates: 4712967..4713725 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIM99_RS22960 (4707350)	4707350..4708870	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
KIM99_RS22965 (4708867)	4708867..4709865	+	999	WP_009309413.1	ribose ABC transporter permease	-
KIM99_RS22970 (4709896)	4709896..4710837	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KIM99_RS22975 (4710912)	4710912..4711919	+	1008	WP_040212412.1	carbohydrate kinase family protein	-
KIM99_RS22980 (4712044)	4712044..4712961	-	918	WP_009309420.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KIM99_RS22985 (4712967)	4712967..4713725	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KIM99_RS22990 (4713811)	4713811..4714539	-	729	WP_002885152.1	response regulator transcription factor	-
KIM99_RS22995 (4714812)	4714812..4716959	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KIM99_RS23000 (4717189)	4717189..4717875	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34738.20 Da
• Isoelectric Point: 5.4746

>T202613 WP_009309420.1 NZ_CP074677:c4712961-4712044 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGEVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVYFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T202613 NZ_CP099529:c4672504-4672370 [Xanthomonas sacchari]
ATGAAGCGTACGTTTGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGGCCGGTTGCAACACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCGGGCGAGAAGGTCCAAGACGCCGCCAAGAACTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT202613 WP_004177809.1 NZ_CP074677:c4713725-4712967 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT202613 NZ_CP099529:c4672712-4672560 [Xanthomonas sacchari]
ATGAAGCGACTGACCACCCTGTTGATGCTGACCCTGTTTTGCGCTGGTGTGCTGACCGGCTGCAACACCGTTGCCGGCGC
CGGCAAGGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACACCGCCAAGGATTGCAGCGCGGGCAAGTGCTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05