Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4556034..4556550 Replicon chromosome
Accession NZ_CP074677
Organism Klebsiella pneumoniae strain MEI009

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag KIM99_RS22170 Protein ID WP_009309309.1
Coordinates 4556034..4556318 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KIM99_RS22175 Protein ID WP_002886901.1
Coordinates 4556308..4556550 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM99_RS22145 (4551429) 4551429..4551692 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KIM99_RS22150 (4551822) 4551822..4551995 + 174 WP_032408826.1 hypothetical protein -
KIM99_RS22155 (4551998) 4551998..4552741 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KIM99_RS22160 (4553098) 4553098..4555236 + 2139 WP_009309308.1 anaerobic ribonucleoside-triphosphate reductase -
KIM99_RS22165 (4555566) 4555566..4556030 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KIM99_RS22170 (4556034) 4556034..4556318 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIM99_RS22175 (4556308) 4556308..4556550 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KIM99_RS22180 (4556628) 4556628..4558538 - 1911 WP_009309311.1 PRD domain-containing protein -
KIM99_RS22185 (4558561) 4558561..4559715 - 1155 WP_009309312.1 lactonase family protein -
KIM99_RS22190 (4559782) 4559782..4560522 - 741 WP_009309313.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T202612 WP_009309309.1 NZ_CP074677:c4556318-4556034 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202612 NZ_CP099525:2034-2348 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202612 WP_002886901.1 NZ_CP074677:c4556550-4556308 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202612 NZ_CP099525:1768-2046 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References