Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4481810..4482501 Replicon chromosome
Accession NZ_CP074677
Organism Klebsiella pneumoniae strain MEI009

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KIM99_RS21835 Protein ID WP_064161707.1
Coordinates 4481810..4482151 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KIM99_RS21840 Protein ID WP_009309815.1
Coordinates 4482175..4482501 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM99_RS21810 (4477363) 4477363..4477884 - 522 WP_048983331.1 TetR/AcrR family transcriptional regulator -
KIM99_RS21815 (4478187) 4478187..4479167 + 981 WP_009309820.1 adenosine deaminase -
KIM99_RS21820 (4479164) 4479164..4479718 + 555 WP_009309819.1 non-canonical purine NTP pyrophosphatase -
KIM99_RS21825 (4479718) 4479718..4480512 + 795 WP_064161706.1 SIR2 family protein -
KIM99_RS21830 (4480860) 4480860..4481693 - 834 WP_009309817.1 DUF4942 domain-containing protein -
KIM99_RS21835 (4481810) 4481810..4482151 - 342 WP_064161707.1 TA system toxin CbtA family protein Toxin
KIM99_RS21840 (4482175) 4482175..4482501 - 327 WP_009309815.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KIM99_RS21845 (4482515) 4482515..4482991 - 477 WP_048982609.1 DNA repair protein RadC -
KIM99_RS21850 (4483002) 4483002..4483448 - 447 WP_009309813.1 antirestriction protein -
KIM99_RS21855 (4483659) 4483659..4484348 - 690 WP_009309812.1 hypothetical protein -
KIM99_RS21860 (4484913) 4484913..4485803 - 891 WP_064161708.1 YfjP family GTPase -
KIM99_RS21865 (4485886) 4485886..4486974 - 1089 WP_064161709.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12932.90 Da        Isoelectric Point: 8.4982

>T202611 WP_064161707.1 NZ_CP074677:c4482151-4481810 [Klebsiella pneumoniae]
MKTLPATTQRAAKPCPSPMTVWQMLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLRAVDILRARQATGLLQYRRNTLSL

Download         Length: 342 bp

>T202611 NZ_CP099524:50882-51031 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12292.01 Da        Isoelectric Point: 6.6290

>AT202611 WP_009309815.1 NZ_CP074677:c4482501-4482175 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDVECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQS

Download         Length: 327 bp

>AT202611 NZ_CP099524:c50837-50778 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References