Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 659065..659768 Replicon chromosome
Accession NZ_CP074677
Organism Klebsiella pneumoniae strain MEI009

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KIM99_RS03240 Protein ID WP_009309675.1
Coordinates 659427..659768 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KIM99_RS03235 Protein ID WP_009309674.1
Coordinates 659065..659406 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM99_RS03210 (654581) 654581..655743 + 1163 WP_087728260.1 IS3 family transposase -
KIM99_RS03215 (656135) 656135..657007 + 873 WP_196983271.1 hypothetical protein -
KIM99_RS03220 (657205) 657205..658026 + 822 WP_009309670.1 DUF932 domain-containing protein -
KIM99_RS03225 (658057) 658057..658499 + 443 Protein_633 antirestriction protein -
KIM99_RS03230 (658512) 658512..659054 + 543 WP_009309673.1 DNA repair protein RadC -
KIM99_RS03235 (659065) 659065..659406 + 342 WP_009309674.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KIM99_RS03240 (659427) 659427..659768 + 342 WP_009309675.1 TA system toxin CbtA family protein Toxin
KIM99_RS03250 (660130) 660130..660636 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
KIM99_RS03255 (660736) 660736..662577 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
KIM99_RS03260 (662796) 662796..664541 - 1746 WP_004149864.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12822.76 Da        Isoelectric Point: 9.6542

>T202596 WP_009309675.1 NZ_CP074677:659427-659768 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAEITLADAVNFLVDKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Download         Length: 342 bp

>T202596 NZ_CP099522:292088-292456 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12735.41 Da        Isoelectric Point: 6.3157

>AT202596 WP_009309674.1 NZ_CP074677:659065-659406 [Klebsiella pneumoniae]
MKSTESENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGAFSNAESLKLDEVFPRFISQMESMLTIGEMNPHH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT202596 NZ_CP099522:291870-292091 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References