Detailed information of TA system TA202592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 598668..599314
• Replicon: chromosome
• Accession: NZ_CP074676
• Organism: Pseudomonas qingdaonensis strain S-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KH389_RS02760
• Protein ID: WP_213606842.1
• Coordinates: 598668..599084 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KH389_RS02765
• Protein ID: WP_088514159.1
• Coordinates: 599084..599314 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KH389_RS02740 (KH389_02740)	595087..597147	-	2061	WP_213606840.1	TonB-dependent copper receptor	-
KH389_RS02745 (KH389_02745)	597230..597646	-	417	WP_088514157.1	DUF2946 domain-containing protein	-
KH389_RS02750 (KH389_02750)	597667..598137	-	471	WP_043863478.1	copper chaperone PCu(A)C	-
KH389_RS02755 (KH389_02755)	598185..598571	-	387	WP_054916153.1	DUF2946 domain-containing protein	-
KH389_RS02760 (KH389_02760)	598668..599084	-	417	WP_213606842.1	tRNA(fMet)-specific endonuclease VapC	Toxin
KH389_RS02765 (KH389_02765)	599084..599314	-	231	WP_088514159.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KH389_RS02770 (KH389_02770)	599398..600111	-	714	WP_213606844.1	cobalt-precorrin-6A reductase	-
KH389_RS02775 (KH389_02775)	600108..601202	-	1095	WP_213606846.1	cobalt-precorrin-5B (C(1))-methyltransferase	-
KH389_RS02780 (KH389_02780)	601195..602406	-	1212	WP_213606847.1	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE	-
KH389_RS02785 (KH389_02785)	602523..603851	+	1329	WP_274611444.1	precorrin-3B synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15254.74 Da
• Isoelectric Point: 7.7291

>T202592 WP_213606842.1 NZ_CP074676:c599084-598668 [Pseudomonas qingdaonensis]
MLKYMLDTNICIFTLKNKPQEVREAFNLHHGQMCISTITLMELMFGAEKSSAPGKNLAVVEGFAARLEVLDYDVPAAAHC
GQLRAELARLGTPIGPYDQMIAGHARSRGLILVSNNLREFARVPGLRTEDWLGQRGCP

Nucleotide

• Length: 417 bp

>T202592 NZ_CP099513:c3529305-3529202 [Klebsiella sp. ZYC-1]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8450.48 Da
• Isoelectric Point: 4.5408

>AT202592 WP_088514159.1 NZ_CP074676:c599314-599084 [Pseudomonas qingdaonensis]
MEQGAVFKSNRSQAIRLPKSVALPPEVKRVDIVAVGRARIITPAGECWDSWFDGDSVTADFMAGREQPADQEREDF

Nucleotide

• Length: 231 bp

>AT202592 NZ_CP099513:3529195-3529363 [Klebsiella sp. ZYC-1]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA