Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 80664..81189 | Replicon | plasmid pCFSAN008081 |
| Accession | NZ_CP074664 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | BG493_RS24040 | Protein ID | WP_001159863.1 |
| Coordinates | 80664..80969 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | BG493_RS24045 | Protein ID | WP_000813641.1 |
| Coordinates | 80971..81189 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BG493_RS24000 (BG493_23985) | 76043..76603 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| BG493_RS24005 (BG493_23990) | 76759..77046 | + | 288 | WP_071530243.1 | hypothetical protein | - |
| BG493_RS24010 (BG493_23995) | 77323..77808 | - | 486 | WP_000905606.1 | membrane protein | - |
| BG493_RS24015 (BG493_24000) | 77802..78290 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| BG493_RS24020 (BG493_24005) | 78477..79028 | - | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| BG493_RS24025 (BG493_24010) | 79037..79819 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| BG493_RS24030 (BG493_24015) | 79854..80375 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| BG493_RS24035 (BG493_24020) | 80372..80662 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| BG493_RS24040 (BG493_24025) | 80664..80969 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| BG493_RS24045 (BG493_24030) | 80971..81189 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| BG493_RS24050 (BG493_24035) | 81865..82386 | + | 522 | WP_010999942.1 | hypothetical protein | - |
| BG493_RS24315 | 82430..82858 | - | 429 | Protein_103 | hypothetical protein | - |
| BG493_RS24055 (BG493_24040) | 82870..83166 | + | 297 | WP_001687482.1 | hypothetical protein | - |
| BG493_RS24060 (BG493_24045) | 83660..84649 | + | 990 | WP_001527061.1 | RepB family plasmid replication initiator protein | - |
| BG493_RS24065 (BG493_24050) | 84908..85352 | - | 445 | Protein_106 | tyrosine-type recombinase/integrase | - |
| BG493_RS24070 (BG493_24055) | 85521..85902 | - | 382 | Protein_107 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | rck / spvB / spvC / fdeC / pefB / pefA / pefC / pefD | 1..93960 | 93960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T202589 WP_001159863.1 NZ_CP074664:c80969-80664 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T202589 NZ_CP099513:27089-27463 [Klebsiella sp. ZYC-1]
ATGATTAAAGGCCCGGCGCTGTTTGATACTAATATTCTCATCGATTTATTCAGCGGTCGCGTTGAAGCGAAACAGGTTCT
GGAGGCTTATCCGCCACAGAATGCGATTAGCCTCATCACGTGGACGGAAGTAATGGTGGGGGCGAAAAAGTATCATCAGG
AACACCGCACGCGTATTGCACTGAGCGCGTTTAATATTATCGATATTTCACAGGATATTGCTGAACGAAGCGTCAATCTC
AGGAAGGAGTATGGGATGAAGCTGCCGGATGCCATCATACTGGCGACAGCGCAAATACATCGTTATGAACTGGTCACGCG
CAATACCAAAGATTTTTTCGGGATACCCGGAGTGATTACGCCTTATCATTTGTAA
ATGATTAAAGGCCCGGCGCTGTTTGATACTAATATTCTCATCGATTTATTCAGCGGTCGCGTTGAAGCGAAACAGGTTCT
GGAGGCTTATCCGCCACAGAATGCGATTAGCCTCATCACGTGGACGGAAGTAATGGTGGGGGCGAAAAAGTATCATCAGG
AACACCGCACGCGTATTGCACTGAGCGCGTTTAATATTATCGATATTTCACAGGATATTGCTGAACGAAGCGTCAATCTC
AGGAAGGAGTATGGGATGAAGCTGCCGGATGCCATCATACTGGCGACAGCGCAAATACATCGTTATGAACTGGTCACGCG
CAATACCAAAGATTTTTTCGGGATACCCGGAGTGATTACGCCTTATCATTTGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT202589 WP_000813641.1 NZ_CP074664:c81189-80971 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT202589 NZ_CP099513:26853-27092 [Klebsiella sp. ZYC-1]
ATGATGACGGGAACGAATATGGGCAGAATACTACTCGACTTATCGGATGACGTTATTAAACGTCTTGAAGACCTCAAACA
GCAGCGCAATCTTCCTCGAGCGGAACTGTTACGCGAGGCGGTTGAACAGTACCTGGAAAGACAAGCTGACACCACTATTT
CCAATGCGCTGGGGATTTGGCAAGGCTGTGAGGAAGATGGAGTTGAATTCGAAAGGAAACTCCGCGAGGAGTGGCAATGA
ATGATGACGGGAACGAATATGGGCAGAATACTACTCGACTTATCGGATGACGTTATTAAACGTCTTGAAGACCTCAAACA
GCAGCGCAATCTTCCTCGAGCGGAACTGTTACGCGAGGCGGTTGAACAGTACCTGGAAAGACAAGCTGACACCACTATTT
CCAATGCGCTGGGGATTTGGCAAGGCTGTGAGGAAGATGGAGTTGAATTCGAAAGGAAACTCCGCGAGGAGTGGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |